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Proceedings Article

Absolute quantification methods in tissue near-infrared spectroscopy

[+] Author Affiliations
Steven J. Matcher, K. Nahid, Mark Cope, David T. Delpy

Univ. College London (United Kingdom)

Peter J. Kirkpatrick

Addenbrookes Hospital (United Kingdom)

Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, 486 (May 30, 1995); doi:10.1117/12.209997
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From Conference Volume 2389

  • Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
  • Britton Chance; Robert R. Alfano
  • San Jose, CA, United States | February 01, 1995

abstract

Recent work aimed at providing an absolute measurement of tissue haemoglobin saturation and a new instrument development, the spatially resolved spectrometer (SRS), are discussed. The theoretical basis of operation of this device and its hardware implementation are described and the results of validation studies on tissue simulating phantoms are presented as are preliminary measurements on human volunteers and observations on patients undergoing neurosurgery. In its present form the instrument appears to produce absolute haemoglobin saturation values for resting human skeletal muscle and the normally perfused human head which are rather low based on physiological expectations. However, we obtained a tight correlation between the saturation values measured by the SRS instrument and those obtained from blood-gas analysis of samples drawn from a jugular bulb catheter in one neurosurgery subject during clamping of the right carotid arteries.

© (1995) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Steven J. Matcher ; Peter J. Kirkpatrick ; K. Nahid ; Mark Cope and David T. Delpy
"Absolute quantification methods in tissue near-infrared spectroscopy", Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, 486 (May 30, 1995); doi:10.1117/12.209997; http://dx.doi.org/10.1117/12.209997


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