Optoacoustic signal profiles for monitoring glucose concentration in turbid media

Kirill V. Larin; Alexander A. Oraevsky

doi:10.1117/12.341445

4 March 1999 Optoacoustic signal profiles for monitoring glucose concentration in turbid media

Proceedings Volume 3726, Saratov Fall Meeting '98: Light Scattering Technologies for Mechanics, Biomedicine, and Material Science; (1999) https://doi.org/10.1117/12.341445
Event: Saratov Fall Meeting '98: Light Scattering Technologies for Mechanics, Biomedicine, and Material Science, 1998, Saratov, Russian Federation

Abstract

Our research project is focused on theoretical and experimental studies into the possibility of in vivo monitoring of blood glucose concentration. Previous experiments demonstrated that the presence of glucose dissolved in aqueous solution of polystyrene microspheres increases the refractive index of this solution due to glucose hydrophilic properties. As a strong osmolyte glucose influences the scattering properties of any particles or fibers suspended in water or biological fluids. We measured profiles of absorbed laser energy distributions as a function of glucose concentration in aqueous solution of polystyrene microspheres colored with potassium chromate. Experiments were performed at the wavelength of the Nd:YAG laser third harmonic, (lambda) equals 355 nm. The results obtained demonstrated a 4.5% decrease in effective optical attenuation coefficient with a 100 mM increase in glucose concentration. These initial results demonstrated that the effect of glucose on optical attenuation of turbid aqueous solutions is small but reliably measurable with the use of the time-resolved optoacoustic technique.

Citation Download Citation

Kirill V. Larin and Alexander A. Oraevsky "Optoacoustic signal profiles for monitoring glucose concentration in turbid media", Proc. SPIE 3726, Saratov Fall Meeting '98: Light Scattering Technologies for Mechanics, Biomedicine, and Material Science, (4 March 1999); https://doi.org/10.1117/12.341445

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