Dr. Alena Rudkouskaya Profile

Dr. Alena Rudkouskaya

at Albany Medical College

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Author

Publications (18)

Proceedings Article | 7 March 2022 Presentation

Multiplexing drug-target engagement and metabolic imaging in HER2-positive tumor xenograft models

Alena Rudkouskaya, Jason Smith, Xavier Intes, Margarida Barroso

Proceedings Volume PC11938, PC1193809 (2022) https://doi.org/10.1117/12.2607308

KEYWORDS: Tumors, Tumor growth modeling, Multiplexing, Fluorescence resonance energy transfer, Systems modeling, Signal detection, Luminescence, Mode conditioning cables, In vivo imaging, Therapeutic antibodies

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Proceedings Article | 7 March 2022 Presentation

Characterization of a large gated SPAD array for in vivo fluorescence lifetime imaging of drug target engagement

Jason Smith, Alena Rudkouskaya, Shan Gao, Arin Ulku, Claudio Bruschini, Edoardo Charbon, Shimon Weiss, Margarida Barroso, Xavier Intes, Xavier Michalet

Proceedings Volume PC11964, PC1196408 (2022) https://doi.org/10.1117/12.2609888

KEYWORDS: In vivo imaging, Fluorescence lifetime imaging, Sensors, In vitro testing, Visible radiation, Tumors, Near infrared, Luminescence, Fluorescence resonance energy transfer, Detector development

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Proceedings Article | 7 March 2022 Presentation

Antibody-target binding in living tumors using macroscopy fluorescence lifetime imaging

Margarida Barroso, Alena Rudkouskaya, Jason Smith, John Williams, Xavier Intes

Proceedings Volume PC11965, PC119650C (2022) https://doi.org/10.1117/12.2609024

KEYWORDS: Tumors, Fluorescence resonance energy transfer, Near infrared, Fluorescence lifetime imaging, Signal detection, Resonance energy transfer, Microscopy, Imaging systems

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Proceedings Article | 12 March 2021 Presentation + Paper

Monitoring receptor heterodimerization along intracellular trafficking pathways using anti-HER2 therapeutic antibodies

Alena Rudkouskaya, Jason Smith, Xavier Intes, Margarida Barroso

Proceedings Volume 11624, 116240F (2021) https://doi.org/10.1117/12.2578402

KEYWORDS: Receptors, Therapeutic antibodies, Fluorescence resonance energy transfer, Cancer, Modulation, Luminescence, Switches, Resonance energy transfer, Resistance

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Proceedings Article | 2 April 2020 Presentation + Paper

Measurements of iron-bound transferrin in breast cancer tumor xenografts using Raman spectral imaging

Kate Tubbesing, Ting Chean Khoo, Alena Rudkouskaya, Anna Sharikova, Margarida Barroso, Alexander Khmaladze

Proceedings Volume 11363, 113630Y (2020) https://doi.org/10.1117/12.2555211

KEYWORDS: Tumors, Raman spectroscopy, Iron, Breast cancer, Tissues, Imaging spectroscopy, Cancer, Confocal microscopy, Veins, Receptors

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Proceedings Article | 9 March 2020 Presentation

Monitoring receptor-ligand interactions using fluorescence lifetime FRET imaging via deep learning (Conference Presentation)

Margarida Barroso, Alena Rudkouskaya, Jason Smith, Xavier Intes

Proceedings Volume 11244, 1124419 (2020) https://doi.org/10.1117/12.2546342

KEYWORDS: Luminescence, Fluorescence resonance energy transfer, Near infrared, Visible radiation, Resonance energy transfer, In vitro testing, In vivo imaging, 3D acquisition, 3D image processing, 3D metrology

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Proceedings Article | 20 February 2020 Presentation + Paper

Raman hyperspectral imaging of transferrin-bound iron in T47D and MDA-MB-231 breast cancer cells

Ting Chean Khoo, Kate Tubbesing, Alena Rudkouskaya, Georgios Athanassiadis, Anna Sharikova, Margarida Barroso, Alexander Khmaladze

Proceedings Volume 11251, 112511E (2020) https://doi.org/10.1117/12.2547638

KEYWORDS: Iron, Raman spectroscopy, Breast cancer, Hyperspectral imaging, Cancer, Imaging spectroscopy, Receptors, Proteins, Tissues, Microscopy

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Proceedings Article | 19 February 2020 Presentation + Paper

Quantification of anti-HER2 drug uptake into human breast cancer cells using fluorescence lifetime FRET imaging

Alena Rudkouskaya, Jason Smith, Marien Ochoa, Xavier Intes, Margarida Barroso

Proceedings Volume 11219, 112190C (2020) https://doi.org/10.1117/12.2544429

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, Breast cancer, Fluorescence lifetime imaging, Confocal microscopy, Cancer, Near infrared, Microscopy, Plasma, Tumors

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Proceedings Article | 4 March 2019 Presentation

Deep learning for quantitative bi-exponential fluorescence lifetime imaging (Conference Presentation)

Jason Smith, Ruoyang Yao, Sez-Jade Chen, Nattawut Sinsuebphon, Alena Rudkouskaya, Margarida Barroso, Pingkun Yan, Xavier Intes

Proceedings Volume 10871, 108710J (2019) https://doi.org/10.1117/12.2509857

KEYWORDS: Fluorescence lifetime imaging, Biomedical optics, Super resolution, Microscopy, Whole body imaging, Resonance energy transfer, Fluorescence resonance energy transfer, Neural networks, Luminescence

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Proceedings Article | 4 March 2019 Presentation

IRDye QC-1 as a near-infrared dark acceptor for fluorescence lifetime FRET measurements in cells and in live intact animals (Conference Presentation)

Sez-Jade Chen, Alena Rudkouskaya, Joseph Mazurkiewicz, Marien Ochoa Mendoza, Nattawut Sinsuebphon, Margarida Barroso, Xavier Intes

Proceedings Volume 10882, 108820N (2019) https://doi.org/10.1117/12.2508056

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, Near infrared, In vivo imaging, Multiplexing, Confocal microscopy, Fluorescence lifetime imaging, Resonance energy transfer, Organisms, Absorbance

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Proceedings Article | 4 March 2019 Presentation

MFLI-FRET as an analytical tool to monitor drug distribution and penetration in tumor xenografts, liver and bladder in intact, live animals (Conference Presentation)

Margarida Barroso, Alena Rudkouskaya, Nattawut Sinsuebphon, Xavier Intes

Proceedings Volume 10859, 108590D (2019) https://doi.org/10.1117/12.2507523

KEYWORDS: Tumors, Liver, Bladder, Breast cancer, Fluorescence resonance energy transfer, Receptors, Near infrared, Microfluidic imaging, Microfluidics, Blood circulation

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Proceedings Article | 1 March 2019 Presentation + Paper

Dynamic macroscopic in vivo FRET for the quantitative monitoring of targeted receptor engagement

Nattawut Sinsuebphon, Alena Rudkouskaya, Margarida Barroso, Xavier Intes

Proceedings Volume 10877, 108770F (2019) https://doi.org/10.1117/12.2510695

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, In vivo imaging, Receptors, Physiology, Imaging systems, Picosecond phenomena, Molecular imaging

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Proceedings Article | 14 March 2018 Presentation

Near infrared fluorescence lifetime FRET imaging of target engagement at multiscale (Conference Presentation)

Margarida Barroso, Alena Rudkouskaya, Jamie Ward, Joseph Mazurkiewicz, Nattawut Sinsuebphon, Sez-Jade Chen, Xavier Intes

Proceedings Volume 10498, 104980R (2018) https://doi.org/10.1117/12.2297567

KEYWORDS: Near infrared, Luminescence, Fluorescence resonance energy transfer, Receptors, Microscopy, In vivo imaging, Cancer, In vitro testing, Proteins, Therapeutic antibodies

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Proceedings Article | 14 March 2018 Presentation

Fast in vivo quantification of receptor engagement by phasor analysis of NIR fluorescence lifetime (Conference Presentation)

Sez-Jade Chen, Nattawut Sinsuebphon, Alena Rudkouskaya, Margarida Barroso, Xavier Intes, Xavier Michalet

Proceedings Volume 10487, 104870I (2018) https://doi.org/10.1117/12.2289084

KEYWORDS: In vivo imaging, Near infrared, Luminescence, Fluorescence resonance energy transfer, Absorption, Receptors, Preclinical imaging, Fluorescent markers, Molecular imaging, Image-guided intervention

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Proceedings Article | 14 March 2018 Presentation

Deep tissue imaging of target engagement in live animals (Conference Presentation)

Margarida Barroso, Xavier Intes, Nattawut Sinsuebphon, Alena Rudkouskaya

Proceedings Volume 10475, 104750A (2018) https://doi.org/10.1117/12.2290807

KEYWORDS: Fluorescence resonance energy transfer, In vivo imaging, Receptors, Cancer, Optical imaging, Tumors, Imaging systems, Deep tissue imaging, Luminescence, Oncology

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Proceedings Article | 19 April 2017 Presentation

Fluorescence lifetime FRET non-invasive imaging of breast cancer xenografts provides a measure of target engagement in vivo (Conference Presentation)

Alena Rudkouskaya, Nattawut Sinsuebphon, Xavier Intes, Margarida Barroso

Proceedings Volume 10049, 1004908 (2017) https://doi.org/10.1117/12.2257114

KEYWORDS: Fluorescence resonance energy transfer, In vivo imaging, Fluorescence lifetime imaging, Breast cancer, Receptors, Cancer, Luminescence, Near infrared, Mammography, Tumors

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Proceedings Article | 21 February 2017 Presentation + Paper

Fluorescence lifetime FRET imaging of receptor-ligand complexes in tumor cells in vitro and in vivo

Alena Rudkouskaya, Nattawut Sinsuebphon, Xavier Intes, Joseph Mazurkiewicz, Margarida Barroso

Proceedings Volume 10069, 1006917 (2017) https://doi.org/10.1117/12.2258231

KEYWORDS: Fluorescence resonance energy transfer, In vivo imaging, Fluorescence lifetime imaging, Therapeutics, Receptors, Optical imaging, Resonance energy transfer, Oncology, Near infrared, Microscopy, Tumors, Cancer

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Proceedings Article | 29 February 2016 Paper

Wide-field lifetime-based FRET imaging for the assessment of early functional distribution of transferrin-based delivery in breast tumor-bearing small animals

Nattawut Sinsuebphon, Alena Rudkouskaya, Margarida Barroso, Xavier Intes

Proceedings Volume 9689, 968945 (2016) https://doi.org/10.1117/12.2217845

KEYWORDS: Fluorescence resonance energy transfer, Breast cancer, Cancer, Resonance energy transfer, Tumors, Data acquisition, Receptors

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Showing 5 of 18 publications

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