Ms. Freshta Baher Profile

Freshta Baher

at Univ of Nebraska Medical Ctr

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Proceedings Article | 7 March 2019 Paper

Efficacy of indocyanine green-loaded hyaluronic acid nanoparticles for the surgical resection of orthotopic breast tumors

Nicholas Wojtynek, Megan Holmes, Madeline Olson, Freshta Baher, Edibaldo Silva, Aaron Mohs

Proceedings Volume 10862, 108621G (2019) https://doi.org/10.1117/12.2509991

KEYWORDS: Tumors, Surgery, Tissues, Breast cancer, Nanoparticles, Cancer, Breast, Oncology, Luminescence, Image-guided intervention

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Breast cancer patients that experience complete removal of the primary tumor, or negative surgical margins (NSMs), benefit from decreased rates of local recurrence and increased survival. However, intraoperative margin detection is limited to visualization, palpation, and experience to identify malignant vs. healthy tissue. As a result, roughly 1/3 of patients treated with breast conserving surgery (BCS) have residual cancer cells left at the resection border, or positive surgical margins (PSMs). Fluorescence image-guided surgery (FIGS) is a promising alternative for intraoperative margin detection, providing surgeons with real-time feedback on tumor location, increasing the likelihood of achieving NSMs. Our past work has demonstrated that the use of self-assembled hyaluronic acid (HA) nanoparticles improves the delivery of indocyanine green (ICG) to breast tumors, enhancing intraoperative tumor signal and contrast. This study built upon these findings by assessing the surgical efficacy of ICG-loaded HA nanoparticles (NanoICG) for the image-guided resection of orthotopic iRFP+/luciferase+ 4T1 breast tumors in BALB/c mice. Tumors were resected with FIGS in mice treated with ICG or NanoICG and compared to bright light surgery (BLS) or sham controls. Tumor growth and recurrence were monitored with bioluminescence imaging. NanoICG improved complete resection and prolonged tumorfree survival. Additionally, NanoICG provided greater intraoperative contrast in malignant tissue than ICG or BLS. Furthermore, NanoICG demonstrated a greater ability to identify small, occult lesions than ICG. Overall, the use of NanoICG for the fluorescence image-guided resection of breast tumors could potentially decrease PSM rates and improve complete tumor removal.

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