Dr. Irina V. Balalaeva Profile

Dr. Irina V. Balalaeva

at NI Lobachevsky State Univ of Nizhni Novgorod

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Publications (14)

Proceedings Article | 22 July 2019 Paper

Hydrogen peroxide level in tumor cells during cisplatin-induced apoptosis

Anastasiya Nerush, Kseniya Shсhukina, Irina Balalaeva, Anna Orlova

Proceedings Volume 11079, 110791M (2019) https://doi.org/10.1117/12.2527195

KEYWORDS: Cell death, Hydrogen, Tumors, Luminescence, Flow cytometry, Sensors, Cancer, Optical filters, Medicine, Applied physics

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Proceedings Article | 7 March 2014 Paper

The study of hydrogen peroxide level under cisplatin action using genetically encoded sensor hyper

A. Belova, A. Orlova, A. Maslennikova, A. Brilkina, I. Balalaeva, N. Antonova, N. Mishina, N. Shakhova, V. Belousov

Proceedings Volume 8956, 895612 (2014) https://doi.org/10.1117/12.2037737

KEYWORDS: Luminescence, Hydrogen, Cell death, Sensors, Flow cytometry, Cervical cancer, Fluorescence spectroscopy, Tumors, Oxygen, Proteins

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Proceedings Article | 11 February 2011 Paper

Study of photosensitizers pharmacokinetics in mouse tumor model by transillumination fluorescence imaging in vivo

Marina Shirmanova, Irina Balalaeva, Marina Sirotkina, Natalya Yu. Lekanova, Ilya Turchin, Elena Zagainova

Proceedings Volume 7886, 78860U (2011) https://doi.org/10.1117/12.873870

KEYWORDS: Tumors, Luminescence, In vivo imaging, Tissues, Tissue optics, Tumor growth modeling, Skin, Photodynamic therapy, Fluorescence spectroscopy, Sensors

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SPIE Journal Paper | 1 July 2010 Open Access

In vivo study of photosensitizer pharmacokinetics by fluorescence transillumination imaging

Marina Shirmanova, Elena Zagainova, Marina Sirotkina, Ludmila Snopova, Irina Balalaeva, Irina Krutova, Nataliya Lekanova, Ilya Turchin, Anna Orlova, Mikhail Kleshnin

JBO, Vol. 15, Issue 04, 048004, (July 2010) https://doi.org/10.1117/12.10.1117/1.3478310

KEYWORDS: Tumors, Luminescence, In vivo imaging, Tissue optics, Tissues, Signal detection, Sensors, Calibration, Photodynamic therapy, Skin

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Proceedings Article | 27 February 2010 Paper

Whole-body imaging of HER2/neu-overexpressing tumors using scFv-antibody conjugated quantum dots

Irina Balalaeva, Tatiana Zdobnova, Anna Brilkina, Irina Krutova, Oleg Stremovskiy, Elena Lebedenko, Vladimir Vodeneev, Ilya Turchin, Sergey Deyev

Proceedings Volume 7575, 757510 (2010) https://doi.org/10.1117/12.840649

KEYWORDS: Tumors, Quantum dots, In vivo imaging, Whole body imaging, Luminescence, Tissues, Proteins, Confocal microscopy, Cancer, Signal detection

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SPIE Journal Paper | 1 March 2009 Open Access

Fluorescent immunolabeling of cancer cells by quantum dots and antibody scFv fragment

Tatiana Zdobnova, S. Dorofeev, P. Tananaev, R. Vasiliev, T. Balandin, Eveline Edelweiss, O. Stremovskiy, Irina Balalaeva, Ilya Turchin, Elena Lebedenko, Vladimir Zlomanov, Sergey Deyev

JBO, Vol. 14, Issue 02, 021004, (March 2009) https://doi.org/10.1117/12.10.1117/1.3122775

KEYWORDS: Cancer, Quantum dots, Luminescence, Proteins, Nanocrystals, Visualization, Receptors, Cadmium sulfide, Tumors, Molecules

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Proceedings Article | 22 February 2008 Paper

Gold nanoshells for OCT imaging contrast: From model to in-vivo study

E. Zagaynova, M. Shirmanova, A. Orlova, I. Balalaeva, M. Yu. Kirillin, V. Kamensky, M. Bugrova, M. Sirotkina

Proceedings Volume 6865, 68650K (2008) https://doi.org/10.1117/12.763004

KEYWORDS: Optical coherence tomography, Skin, Gold, Monte Carlo methods, In vivo imaging, Nanoparticles, Optical properties, Scattering, Tissue optics, Computer simulations

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Proceedings Article | 1 August 2007 Paper

Diffuse fluorescence tomography of exo- and endogenously labeled tumors

Irina Balalaeva, Ilya Turchin, Anna Orlova, Vladimir Plekhanov, Marina Shirmanova, Michail Kleshnin, Ilya Fiks, Elena Zagainova, Vladislav Kamensky

Proceedings Volume 6734, 67340K (2007) https://doi.org/10.1117/12.753220

KEYWORDS: Tumors, Quantum dots, Tumor growth modeling, Tissues, Fluorescent proteins, Animal model studies, In vivo imaging, Proteins, Tissue optics, Luminescence

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Strong light scattering and absorption limit observation of the internal structure of biological tissue. Only special tools for turbid media imaging, such as optical diffuse tomography, enable noninvasive investigation of the internal biological tissues, including visualization and intravital monitoring of deep tumors. In this work the preliminary results of diffuse fluorescence tomography (DFT) of small animals are presented. Usage of exogenous fluorophores, targeted specifically at tumor cells, and fluorescent proteins expressed endogenously can significantly increase the contrast of obtained images. Fluorescent compounds of different nature, such as sulphonated aluminium phthalocyanine (Photosens), red fluorescing proteins and CdTe/CdSe-core/shell nanocrystals (quantum dots) were applied. We tested diffuse fluorescence tomography method at model media, in post mortem and in vivo experiments. The animal was scanned in transilluminative configuration by low-frequency modulated light (1 kHz) from Nd:YAG laser with second harmonic generation at wavelength of 532 nm or semiconductor laser at wavelength of 655 nm. Quantum dots or protein DsRed2 in glass capsules (inner diameter 2-3 mm) were placed post mortem inside the esophagus of 7-day-old hairless rats to simulate marked tumors. Photosens was injected intravenously to linear mice with metastazing Lewis lung carcinoma. The reconstruction algorithm, based on Algebraic Reconstruction Technique, was created and tested numerically in model experiments. High contrast images of tumor simulating capsules with DsRed2 concentrations about 10^-6 M and quantum dots about 5x10^-11 M have been obtained. Organ distribution of Photosens and its accumulation in tumors and surrounding tissues of animals has been examined. We have conducted the monitoring of tumors, exogenously labeled by photosensitizer. This work demonstrates potential capabilities of DFT method for intravital detection and monitoring of deep fluorescent-labeled tumors in animal models. The comparative analysis of conventional photosensitizer, fluorescent proteins and quantum dots has been carried out.

Proceedings Article | 13 July 2007 Paper

In vivo study of contrasting properties of gold nanoparticles for optical coherence tomography

E. Zagaynova, M. Shirmanova, A. Orlova, I. Balalaeva, M. Kirillin, V. Kamensky

Proceedings Volume 6633, 663316 (2007) https://doi.org/10.1117/12.728196

KEYWORDS: Skin, Nanoparticles, Optical coherence tomography, Monte Carlo methods, Gold, Particles, In vivo imaging, Optical properties, Scattering, Silica

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We have investigated the effect of application of gold nanoparticles with a diameter of 50 nm and nanoshells with a 150 nm silica core size and 25 nm thick gold shell on optical properties of skin. We have analyzed the possibility of using these particles as a contrasting agent for optical coherence tomography (OCT). As the first step in the study, effects of gold nanoparticles after one application to skin were studied using OCT. Then we evaluated the effects of multiple applications of 50 nm gold nanoparticles to skin in 30-minute intervals. Biopsy of relevant skin areas was performed under local anaesthesia and samples for light and electron microscopy were prepared. Identification of skin layers on OCT images was made by comparing with histology. Application of gold-silica nanoshells caused increase in intensity of useful signal, brightness of the superficial part of the dermis and contrast between the superficial and deep parts of the dermis 30 minutes after application on skin. After 24 hours the changes in OCT images became more pronounced as the brightness of the superficial part of the dermis and the contrast between the superficial and deep parts of the dermis further increased. In addition, the border between the superficial and deep parts of the dermis became more distinct, continuous and well discernible, permitting to accurately differentiate these layers. Besides that, the application of nanoshells caused contrasting of hair follicles and glands. In order to give interpretation to the obtained experimental OCT-images of skin and understand the mechanisms of contrasting a set of Monte Carlo calculations was performed in order to simulate the images of skin before and after application of the nanoparticles for skin model close to that in the experiment. The results of the simulation exhibit good qualitative agreement with the experimental images and prove that the contrasting originates from the nanoparticles added while contrasting of hair bulb originates from the absence of nanoparticles in it with their presence in surrounding area.

Proceedings Article | 7 May 2007 Paper

Fluorescence diffuse tomography for tumor detection and monitoring

Irina Balalaeva, Anna Orlova, Marina Shirmanova, Elena Kibraeva, Elena Zagainova, Ilya Turchin

Proceedings Volume 6535, 653509 (2007) https://doi.org/10.1117/12.740615

KEYWORDS: Tumors, Luminescence, Quantum dots, Fluorescent proteins, Proteins, Tomography, Tissues, Tissue optics, Cancer, Fluorescence tomography

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Proceedings Article | 1 May 2007 Paper

Frequency domain fluorescence diffuse tomography of small animals

Anna Orlova, Ilya Turchin, Vladislav Kamensky, Vladimir Plehanov, Irina Balalaeva, Ekaterina Sergeeva, Marina Shirmanova, Michail Kleshnin

Proceedings Volume 6534, 65343G (2007) https://doi.org/10.1117/12.741469

KEYWORDS: Luminescence, Tumors, Animal model studies, Scattering, Tomography, Sensors, Modulation, Glasses, Cancer, Diffusion

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Proceedings Article | 12 February 2007 Paper

Optical coherence tomography in the diagnosis of dysplasia and adenocarcinoma in Barret's esophagus

N. Gladkova, E. Zagaynova, G. Zuccaro, Margarita Kareta, F. Feldchtein, Irina Balalaeva, Elena Balandina

Proceedings Volume 6432, 64320A (2007) https://doi.org/10.1117/12.700254

KEYWORDS: Optical coherence tomography, Endoscopy, Esophagus, Diagnostics, Biopsy, Statistical analysis, Surveillance, Visualization, Ultrasonography, Cancer

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Proceedings Article | 22 February 2006 Paper

OCT visualization of mucosal radiation damage in patients with head and neck cancer: pilot study

Natalia Gladkova, Anna Maslennikova, Irina Balalaeva, Yulia Vyseltseva, Natalia Kornoukhova, Roman Larin, Anna Terentieva, Nina Khomutinnikova, Yulia Fomina, Vladislav Kamensky, Grigory Gelikonov, Felix Feldchtein

Proceedings Volume 6078, 60781J (2006) https://doi.org/10.1117/12.647601

KEYWORDS: Optical coherence tomography, Radiotherapy, Visualization, Cancer, Tissues, Tumors, Head, Neck, Photons, Tissue optics

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Proceedings Article | 7 October 2005 Paper

OCT visualization of acute radiation mucositis: pilot study

Natalia Gladkova, Anna Maslennikova, Anna Terentieva, Yulia Fomina, Nina Khomutinnikova, Irina Balalaeva, Yulia Vyseltseva, Roman Larin, Natalia Kornoukhova, Andrey Shakhov, Natalia Shakhova, Grigory Gelikonov, Vladislav Kamensky, Felix Feldchtein

Proceedings Volume 5861, 58610T (2005) https://doi.org/10.1117/12.632987

KEYWORDS: Optical coherence tomography, Radiotherapy, Visualization, Cancer, Tumors, Tissues, Photons, Oncology, Head, Neck

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Showing 5 of 14 publications

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