Dr. Sergey Mozharov Profile

Dr. Sergey Mozharov

at Univ of Washington

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 15 February 2011 Paper

Process analysis in micro-reactors: challenges and solutions with Raman spectrometry

Sergey Mozharov, Alison Nordon, John Girkin, David Littlejohn

Proceedings Volume 7929, 79290U (2011) https://doi.org/10.1117/12.874227

KEYWORDS: Raman spectroscopy, Microfluidics, Chemical analysis, Spectroscopy, Process control, Sensors, Glasses, Integrated optics, Luminescence, Mass spectrometry

Read Abstract +

With the increasing interest in the exploitation of micro-reactors, there is a growing demand for process monitoring and control methods suitable for application in this environment. At present off-line analysis methods such as chromatography and mass spectrometry are the dominant tools in the field. Although these methods provide exceptionally rich chemical information they require removal of samples from the system and the analysis is not instantaneous. In many microfluidic applications these limitations outweigh their benefits due to the importance of real-time detection and the desired ability to analyze the fluid in different locations in the micro-reactor non-invasively. Therefore optical detection methods such as fluorescence and Raman spectroscopy are becoming increasingly popular in this field, with most attention being drawn to miniature integrated optical sensors. However, integration of sensors into a micro-reactor can change the flow conditions and make the system difficult to scale out. It is also impossible to move the integrated sensor along the flow path. These issues make on-chip process analysis a challenging subject that is still at the early stages of development. This paper discusses opportunities for non-invasive process analysis in micro-reactors focusing the main attention on Raman spectrometry as a powerful technique, whose potential in this field has not been widely recognized yet. With a specially developed probe we demonstrate ability to monitor fluid delivery stability and perform fast real-time analysis of a model esterification reaction. The discussed approach brings unique benefits to kinetics studies, efficient process optimization and process control.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years