Prof. Umberto Romeo Profile

Prof. Umberto Romeo

at Sapienza University of Rome

SPIE Involvement:

Author

Publications (7)

Proceedings Article | 22 March 2016 Paper

Photodynamic therapy in the treatment of epithelial potentially malignant disorders of the mouth: advantages and disadvantages

G. Gaimari, C. Russo, G. Palaia, G. Tenore, A. Del Vecchio, U. Romeo

Proceedings Volume 9670, 96700L (2016) https://doi.org/10.1117/12.2192039

KEYWORDS: Photodynamic therapy, Oxygen, Tissues, Semiconductor lasers, Laser therapeutics, Mouth, Molecular lasers, Photosensitizer targeting, Clinical trials, Cancer

Read Abstract +

Introduction: Leukoplakia is a potentially malignant epithelial lesion with carcinomatous percentages transformation comprehended between 1% and 7% for the homogeneous forms and from 4% to 15% for the non-homogeneous ones. Their removal can be performed by scalpel or laser surgery (excision or vaporization). Photodynamic therapy (PDT) is a bloodless treatment option, based on the involvement of three elements: light, photosensitizer and oxygen. When the molecules of the photosensitizer are activated by a low power laser, energy is transferred to molecular oxygen creating highly reactive radicals of oxygen, that have a cytotoxic effect on target cells.

Aim of the study: According to several studies in Literature, it has been decided to evaluate through an initial clinical trial, the efficacy of PDT using topical aminolevulinic acid (5-ALA) activated by a laser diode (λ = 635 nm) to treat potentially oral malignant lesions and to illustrate the advantages and disadvantages derived from the use of this technique.

Materials and Methods: Five patients, affected by oral leukoplakia (OL) and oral verrucous leukoplakia (OVL) on the mucosal cheeks, labial commissure, fornix and retromolar areas, have been treated using the PDT. Irradiation time with Diode laser: 1000s. Irradiation mode: Scanning. 5 cycles of 3 minute + final cycle of 100 seconds. Each cycle has been interrupted by pauses of 3 minutes.

Results and conclusion: PDT results to be effective in the treatment of OL, especially on OVL. In fact, OVL, due to its irregularity, has got an area of increased retention for the gel that is more difficult to be removed by salivary flow. This could explain the better results obtained in this case rather than in those ones of OL. Furthermore, the advantages have been represented by: less invasivity, high sensitivity for altered tissues, minimal scar tissue, less side effects and no pain during and after operation. In contrast to this, the disadvantages were: longer treatment duration and the high cost.

Proceedings Article | 22 March 2016 Paper

Oral vascular malformations: laser treatment and management

U. Romeo, F. Rocchetti, G. Gaimari, G. Tenore, G. Palaia, G. Lo Giudice

Proceedings Volume 9670, 967003 (2016) https://doi.org/10.1117/12.2191879

KEYWORDS: Laser therapeutics, Lymphatic system, Capillaries, Laser coagulation, Tumors, Semiconductor lasers, Fiber lasers, Circulatory system, Surgery, Biopsy

Read Abstract +

Proceedings Article | 22 March 2016 Paper

Photodynamic therapy in non-surgical treatment of chronic periodontitis: short term randomized clinical trial study

C. Russo, G. Palaia, E. Loskutova, F. Libotte, R. Kornblit, G. Gaimari, G. Tenore, U. Romeo

Proceedings Volume 9670, 96700D (2016) https://doi.org/10.1117/12.2191113

KEYWORDS: Photodynamic therapy, Inflammation, Bacteria, Teeth, Oxygen, Clinical trials, Pathogens, Calculus, Semiconductor lasers, Statistical analysis

Read Abstract +

Proceedings Article | 22 March 2016 Paper

Treatments of the oral leukoplakia by laser

M. Capocci, M. Mohsen, R. Lo Giudice, A. Del Vecchio, G. Gaimari, L. Tribolati, G. Palaia, U. Romeo

Proceedings Volume 9670, 967009 (2016) https://doi.org/10.1117/12.2189243

KEYWORDS: Laser therapeutics, Photodynamic therapy, Semiconductor lasers, Surgery, Biopsy, Tissues, Laser vision correction, Laser applications, Injuries, Biological research

Read Abstract +

Proceedings Article | 22 March 2016 Paper

The use of laser CO2 in salivary gland diseases

C. Ciolfi, F. Rocchetti, M. Fioravanti, G. Tenore, G. Palaia, U. Romeo

Proceedings Volume 9670, 96700F (2016) https://doi.org/10.1117/12.2191499

KEYWORDS: Carbon dioxide lasers, Laser dentistry, Laser therapeutics, Gas lasers, Surgery, Tissues, Carbon monoxide, Tumors, Calculi, Continuous wave operation

Read Abstract +

Salivary gland diseases can include reactive lesions, obstructive lesions, and benign tumors. All these clinical entities are slow growing. Salivary glands reactive lesions, such as mucoceles, can result from extravasation of saliva into the surrounding soft tissue or from retention of saliva within the duct. Sialolithiasis, one of the most common obstructive lesions, is generally due to calculi, which are attributed to retention of saliva. Monomorphic adenoma is a salivary gland benign tumor, which is exclusively resulted from proliferation of epithelial cells, with no alterations interesting the connective tissue. The elective therapy of these lesions is surgical excision because sometimes they can be accompained by difficulties during chewing and phonation and can interfere with prosthesis’s stability.

The aim of the study is to evaluate the efficacy of CO₂ laser in the treatment of patients with salivary gland diseases. Three different cases – a mucocele, a scialolithiasis and a monomorphic adenoma – were treated with CO₂ laser excision (CW and 4W), under local anesthesia. Two different techniques were used: circumferential incision for the adenoma, and mucosa preservation technique for mucocele and sialolithiasis. In each case final haemostasis was obtained by thermocoagulation, but suture was applied to guarantee good healing by sewing up the flaps. The patients were checked after twenty days and the healing was good.

The carbon dioxide laser (CO₂ laser) was one of the earliest gas laser to be developed, and is still the highest-power continuous wave laser that is currently available. In dentistry the CO₂ laser produces a beam of infrared light with the principal wavelength bands centering around 9.4 and 10.6 micrometers. Laser excision can be very useful in oral surgery. In the cases presented CO₂ laser offered, differently from traditional surgery, simplified surgical technique, shorter duration of operation, minimal postoperative pain, minimal scarring, bloodless field and the possibility to realize minimally invasive surgery. These advantages made the operation tolerable for the patients, that became more compliant. Optimum functional results can be expected.

Proceedings Article | 14 January 2014 Paper

Diode laser photocoagulation in PHACES syndrome hemangiomas: a case series

U. Romeo, N. Russo, A. Polimeni, G. Favia, M. G. Lacaita, L. Limongelli, S. Franco

Proceedings Volume 8925, 89250A (2014) https://doi.org/10.1117/12.2044045

KEYWORDS: Laser coagulation, Laser induced plasma spectroscopy, Semiconductor lasers, Laser therapeutics, Optical fibers, Tongue, Eye, Toxicity, Visualization, Mouth

Read Abstract +

Proceedings Article | 14 January 2014 Paper

Laser treatment of oral vascular malformations

U. Romeo, G. Gaimari, M. Mohsen, G. Tenore, G. Palaia

Proceedings Volume 8925, 892503 (2014) https://doi.org/10.1117/12.2042792

KEYWORDS: Laser therapeutics, Ferroelectric materials, Semiconductor lasers, Surgery, Laser coagulation, Capillaries, Lymphatic system, Magnetic resonance imaging, Laser tissue interaction, Ultrasonography

Read Abstract +

Showing 5 of 7 publications

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years