Novel optical imaging methods for photoimmunotherapy monitoring

Qinggong Tang; Feng Yan; Chen Wang; Shulian Wu; Ryuhei Okada; Tadanobu Nagaya; Yuhong Fang; Hui Li; Yu Chen; Hisataka Kobayashi

doi:10.1117/12.2607879

7 March 2022 Novel optical imaging methods for photoimmunotherapy monitoring

Qinggong Tang, Feng Yan, Chen Wang, Shulian Wu, Ryuhei Okada, Tadanobu Nagaya, Yuhong Fang, Hui Li, Yu Chen, Hisataka Kobayashi

Author Affiliations +

Proceedings Volume PC11961, Biophotonics and Immune Responses XVII; PC1196106 (2022) https://doi.org/10.1117/12.2607879
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Near-infrared photoimmunotherapy (NIR-PIT) is an emerging cancer therapy based on conjugating monoclonal antibody (mAb) with a NIR phthalocyanine dye conjugate. Direct tumor necrosis and immunogenic cell death occur during NIR irradiation. We applied a multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence mesoscopic tomography, to provide 3D tumor micro-structure and micro-distribution of mAb-IR700 in the tumor simultaneously during and after NIR-PIT in situ and in vivo. Moreover, label-free speckle variance algorithm combined OCT was applied to monitor the change of blood vessels and the alterations of the blood volume inside the blood vessels during and NIR-PIT treatment.

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Citation Download Citation

Qinggong Tang, Feng Yan, Chen Wang, Shulian Wu, Ryuhei Okada, Tadanobu Nagaya, Yuhong Fang, Hui Li, Yu Chen, and Hisataka Kobayashi "Novel optical imaging methods for photoimmunotherapy monitoring", Proc. SPIE PC11961, Biophotonics and Immune Responses XVII, PC1196106 (7 March 2022); https://doi.org/10.1117/12.2607879

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