PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
Optogenetic control of neuronal activity requires efficient light energy transmission through head tissues and bone. Here we evaluate the efficiency of ultrashort pulsed and continuous-wave light transmittance through the mouse scalp, skull, and brain tissues in near-IR optical windows. The outcomes of the experiments and computer modelling show that the brain cortex tissues can be exposed to 10-12% of the original laser irradiation. This finding together with the latest discovery of non-linear phytochrome conversion [S.Sokolovski et al. 2021] prove the possibility of phytochrome optogenetics in living animals and may be applied in the future for non-invasive photo-controlling of neural cells.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
Diana Galiakhmetova, Viktor Dremin, Aleksandr Koviarov, Dmitrii Stoliarov, Neville Ngum, Rheinallt Parri, Sergei Sokolovski, Edik Rafailov, "Ultrashort pulsed laser in deep head tissues penetration for non-invasive optogenetics in near-IR windows," Proc. SPIE PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC123730A (6 March 2023); https://doi.org/10.1117/12.2666376