Exploring visual-evoked hemodynamic responses in mouse brain using photoacoustic computed tomography

Kai-Wei Chang; Zhongming Liu; Xueding Wang; Kwoon Y. Wong; Guan Xu

doi:10.1117/12.3001921

13 March 2024 Exploring visual-evoked hemodynamic responses in mouse brain using photoacoustic computed tomography

Kai-Wei Chang, Zhongming Liu, Xueding Wang, Kwoon Y. Wong, Guan Xu

Proceedings Volume PC12828, Neural Imaging and Sensing 2024; PC128280B (2024) https://doi.org/10.1117/12.3001921
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

This study presents a novel method using Photoacoustic Computed Tomography (PACT) with a linear ultrasound (US) transducer array to observe visual-evoked hemodynamic responses in the deep mouse brain. By applying advanced data processing techniques, we successfully isolated hemodynamic responses within critical visual regions. The PACT system's high spatial resolution and deep tissue penetration enabled non-invasive examination of visual-evoked brain activity. Our findings demonstrate the potential of PACT for advancing optical neuroimaging and studying synaptic physiology, brain activities, and retinal diseases.

Conference Presentation

Citation Download Citation

Kai-Wei Chang, Zhongming Liu, Xueding Wang, Kwoon Y. Wong, and Guan Xu "Exploring visual-evoked hemodynamic responses in mouse brain using photoacoustic computed tomography", Proc. SPIE PC12828, Neural Imaging and Sensing 2024, PC128280B (13 March 2024); https://doi.org/10.1117/12.3001921

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