Dual modality endoscopic imaging combining optical coherence tomography and near infrared fluorescence

Tyla Danskin; Andrea J. Sterkenburg; Wouter B. Nagengast; Johannes F. de Boer

doi:10.1117/12.3005435

13 March 2024 Dual modality endoscopic imaging combining optical coherence tomography and near infrared fluorescence

Tyla Danskin, Andrea J. Sterkenburg, Wouter B. Nagengast, Johannes F. de Boer

Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC128300F (2024) https://doi.org/10.1117/12.3005435
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Optical Coherence Tomography (OCT) is a low coherence interferometric imaging modality used to obtain micron-resolution structural information in depth, however it lacks in molecular specificity, and can therefore be combined with Near Infrared Fluorescence (NIRF) imaging, using labelled monoclonal antibodies to provide molecular contrast. Here, a novel capsule endoscope design is presented, which facilitates circumferential Immuno-OCT imaging in the gastrointestinal tract. The capsule endoscope is fitted with a double clad fiber to achieve dual modality imaging. We present preliminary endoscopic data for both imaging modalities, for which we have used phantoms to validate the imaging capabilities of the capsule endoscope.

Conference Presentation

Citation Download Citation

Tyla Danskin, Andrea J. Sterkenburg, Wouter B. Nagengast, and Johannes F. de Boer "Dual modality endoscopic imaging combining optical coherence tomography and near infrared fluorescence", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC128300F (13 March 2024); https://doi.org/10.1117/12.3005435

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