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13 March 2024 Core-thermoresponsive shell polymeric nanoparticles loaded with imaging and therapeutic agents for biomedical applications
Tymish Y. Ohulchanskyy, Ludmyla O. Vretik
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Proceedings Volume PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; PC128620D (2024) https://doi.org/10.1117/12.3003772
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
The results on design, synthesis, characterization and biomedical applications of core-thermoresponsive shell polymeric nanoparticles (CTS-PNPs) loaded with imaging and therapeutic agents will be presented. In CTS-PNPs, the polystyrene core (~30 nm) is coated with the shell of poly-N-isopropylacrylamide (PNIPAM) or co-polymer of NIPAM and acrylamide (AA). The shell “shrinks” in water at the temperatures higher than lower critical solution temperature, which can be tuned through co-polymerization of NIPAM with AA, and affects photophysics of the embedded fluorophores. This phenomenon has been employed by us in fluorescence imaging and photodynamic therapy of cancer using CTS-PNPs loaded with fluorescent dyes and photosensitizers.
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Tymish Y. Ohulchanskyy and Ludmyla O. Vretik "Core-thermoresponsive shell polymeric nanoparticles loaded with imaging and therapeutic agents for biomedical applications", Proc. SPIE PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, PC128620D (13 March 2024); https://doi.org/10.1117/12.3003772
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KEYWORDS
Nanoparticles
Biomedical optics
Polymers
Biomedical applications
Therapeutic agents
Fluorescence imaging
Molecules
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