Laser 'combs through' breath: a novel technology for biomedical diagnostics

Konstantin L. Vodopyanov

doi:10.1117/12.3003325

13 March 2024 Laser 'combs through' breath: a novel technology for biomedical diagnostics

Konstantin L. Vodopyanov

Proceedings Volume PC12863, Quantum Effects and Measurement Techniques in Biology and Biophotonics; PC1286302 (2024) https://doi.org/10.1117/12.3003325
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Human exhaled breath contains more than 1,000 volatile organic molecules (biomarkers), combinations of which reflect metabolic processes in the human body. Spectroscopic detection of these biomarkers may be the basis for early diagnosis of various medical conditions. Our detection method, dual-comb spectroscopy (DCS) through the ultra-wideband, 1–100 THz (3–300 µm), spectral range, which targets the strongest vibrational and rotational molecular absorption resonances, relies on optical rectification of few-optical-cycle laser pulses to create mid-IR/THz frequency combs that are subsequently detected by electro-optical sampling (EOS), where the electric field of mid-IR/THz transients induces a change of polarization state of the near-IR probe pulse in the EO crystal. With this technique, we simultaneously achieved superior spectral resolution (via resolving comb lines), real-time detection, broadband (near octave) instantaneous coverage, and massive parallelism of data acquisition. Theoretically, EOS method is sensitive enough to detect vacuum fluctuations, which opens up wide opportunities for the study of quantum effects in biology.

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Konstantin L. Vodopyanov "Laser 'combs through' breath: a novel technology for biomedical diagnostics", Proc. SPIE PC12863, Quantum Effects and Measurement Techniques in Biology and Biophotonics, PC1286302 (13 March 2024); https://doi.org/10.1117/12.3003325

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KEYWORDS

Biomedical optics

Diagnostics

Laser applications

Quantum detection

Electric fields

Single photon detectors

Spectroscopy

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