Non-invasive assessment of the liver using imaging

Camilla Thorling Thompson; Haolu Wang; Xin Liu; Xiaowen Liang; Darrell HG Crawford; Michael S. Roberts

doi:10.1117/12.2242883

9 December 2016 Non-invasive assessment of the liver using imaging

Camilla Thorling Thompson, Haolu Wang, Xin Liu, Xiaowen Liang, Darrell HG Crawford, Michael S. Roberts

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Proceedings Volume 10013, SPIE BioPhotonics Australasia; 100131J (2016) https://doi.org/10.1117/12.2242883
Event: SPIE BioPhotonics Australasia, 2016, Adelaide, Australia

Abstract

Chronic liver disease causes 2,000 deaths in Australia per year and early diagnosis is crucial to avoid progression to cirrhosis and end stage liver disease. There is no ideal method to evaluate liver function. Blood tests and liver biopsies provide spot examinations and are unable to track changes in function quickly. Therefore better techniques are needed. Non-invasive imaging has the potential to extract increased information over a large sampling area, continuously tracking dynamic changes in liver function. This project aimed to study the ability of three imaging techniques, multiphoton and fluorescence lifetime imaging microscopy, infrared thermography and photoacoustic imaging, in measuring liver function. Collagen deposition was obvious in multiphoton and fluorescence lifetime imaging in fibrosis and cirrhosis and comparable to conventional histology. Infrared thermography revealed a significantly increased liver temperature in hepatocellular carcinoma. In addition, multiphoton and fluorescence lifetime imaging and photoacoustic imaging could both track uptake and excretion of indocyanine green in rat liver. These results prove that non-invasive imaging can extract crucial information about the liver continuously over time and has the potential to be translated into clinic in the assessment of liver disease.

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Camilla Thorling Thompson, Haolu Wang, Xin Liu, Xiaowen Liang, Darrell HG Crawford, and Michael S. Roberts "Non-invasive assessment of the liver using imaging", Proc. SPIE 10013, SPIE BioPhotonics Australasia, 100131J (9 December 2016); https://doi.org/10.1117/12.2242883

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KEYWORDS

Liver

Fluorescence lifetime imaging

Photoacoustic imaging

Thermography

Collagen

In vivo imaging

Imaging systems

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