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During the last few years, several promising modalities for the treatment of neoplastic tissue with non-ionizing radiation have been developed. Hyperthermia as a clinical modality is based upon a selective tumor response during a very mode- rate heating of tissue. Selective tumor response has been reported by heating the malignant tissue to a moderate temperature in the region 41-47 °C for some tens of minutes, typically 20-30 Min.1'7,9 The temperature rise is therefore usually below the threshold for coagulation and denaturation of proteins, and the optical power density is certainly at a level well below the threshold value for non-linear mechanisms such as plasma formation and shock wave generation.
Lars O. Svaasand
"Thermotics of tissue", Proc. SPIE 10305, Dosimetry of Laser Radiation in Medicine and Biology, 103050B (10 January 1989); https://doi.org/10.1117/12.2283592
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Lars O. Svaasand, "Thermotics of tissue," Proc. SPIE 10305, Dosimetry of Laser Radiation in Medicine and Biology, 103050B (10 January 1989); https://doi.org/10.1117/12.2283592