In-vivo label-free optical detection of neural activities in retina  (Conference Presentation)

Subrata Batabyal; Sivakumar Gajjeraman; Weldon Wright; Samarendra K. Mohanty

doi:10.1117/12.2291755

14 March 2018 In-vivo label-free optical detection of neural activities in retina (Conference Presentation)

Subrata Batabyal, Sivakumar Gajjeraman, Weldon Wright, Samarendra K. Mohanty

Proceedings Volume 10482, Optogenetics and Optical Manipulation 2018; 104820J (2018) https://doi.org/10.1117/12.2291755
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Monitoring of visual functioning of the retina is significant for characterizing retinal degenerative diseases. Electroretinogram is the current method for measuring the electrical responses of the retina to light. However, it requires placement of electrodes on cornea, leading to contact related uncomfortable feeling. Here, we report use of near-infrared low-coherent light for non-contact, label-free in-vivo detection of retinal activities in response to visual stimulation. We utilized phase sensitive optical coherence tomography for measuring fluctuations of light reflected from retina of wild type and retinal degenerated mice. With visual stimulation, fluctuations in optical path length difference were found to be higher than that without visual stimulation in wild type mice. However, no such changes observed in mice with photoreceptor degeneration. Our findings open up possibility for clinical use of this method for non-contact label free characterization of retinal functioning and identification of dystrophies.

Conference Presentation

Citation Download Citation

Subrata Batabyal, Sivakumar Gajjeraman, Weldon Wright, and Samarendra K. Mohanty "In-vivo label-free optical detection of neural activities in retina (Conference Presentation)", Proc. SPIE 10482, Optogenetics and Optical Manipulation 2018, 104820J (14 March 2018); https://doi.org/10.1117/12.2291755

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Retina

Visualization

In vivo imaging

Cornea

Electrodes

Optical coherence tomography

Visual optics

Keywords/Phrases

Search In:

Publication Years