High sensitivity optical molecular imaging system

Yu An; Gao Yuan; Chao Huang; Shixin Jiang; Peng Zhang; Kun Wang; Jie Tian

doi:10.1117/12.2288908

13 February 2018 High sensitivity optical molecular imaging system

Yu An, Gao Yuan, Chao Huang, Shixin Jiang, Peng Zhang, Kun Wang, Jie Tian

Proceedings Volume 10487, Multimodal Biomedical Imaging XIII; 104870L (2018) https://doi.org/10.1117/12.2288908
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Optical Molecular Imaging (OMI) has the advantages of high sensitivity, low cost and ease of use. By labeling the regions of interest with fluorescent or bioluminescence probes, OMI can noninvasively obtain the distribution of the probes in vivo, which play the key role in cancer research, pharmacokinetics and other biological studies. In preclinical and clinical application, the image depth, resolution and sensitivity are the key factors for researchers to use OMI. In this paper, we report a high sensitivity optical molecular imaging system developed by our group, which can improve the imaging depth in phantom to nearly 5cm, high resolution at 2cm depth, and high image sensitivity. To validate the performance of the system, special designed phantom experiments and weak light detection experiment were implemented. The results shows that cooperated with high performance electron-multiplying charge coupled device (EMCCD) camera, precision design of light path system and high efficient image techniques, our OMI system can simultaneously collect the light-emitted signals generated by fluorescence molecular imaging, bioluminescence imaging, Cherenkov luminance and other optical imaging modality, and observe the internal distribution of light-emitting agents fast and accurately.

Conference Presentation

Citation Download Citation

Yu An, Gao Yuan, Chao Huang, Shixin Jiang, Peng Zhang, Kun Wang, and Jie Tian "High sensitivity optical molecular imaging system", Proc. SPIE 10487, Multimodal Biomedical Imaging XIII, 104870L (13 February 2018); https://doi.org/10.1117/12.2288908

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