Biodynamic imaging of therapeutic efficacy for canine B-cell lymphoma: preclinical trial results

H. Choi; J. Turek; Z. Li; M. Childress; D. Nolte

doi:10.1117/12.2291061

13 February 2018 Biodynamic imaging of therapeutic efficacy for canine B-cell lymphoma: preclinical trial results

H. Choi, J. Turek, Z. Li, M. Childress, D. Nolte

Author Affiliations +

Proceedings Volume 10493, Dynamics and Fluctuations in Biomedical Photonics XV; 1049304 (2018) https://doi.org/10.1117/12.2291061
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Biodynamic imaging uses coherence-gated dynamic light scattering to create three dimensional maps of intracellular dynamics in living tissue biopsies. The technique is sensitive to changes in intracellular dynamics dependent on the mechanism of action (MoA) of therapeutics applied in vitro to the living samples. A preclinical trial in the assessment of chemotherapeutic response of dogs with B-cell lymphoma to the doxorubicin-based therapy CHOP has been completed using biodynamic imaging. The trial enrolled 19 canine patients presenting with non-Hodgkin’s B-cell lymphoma. Biopsies were acquired through surgery or through needle cores. The time-varying power spectrum of scattered light after drugs are applied ex vivo to the biopsies represent biodynamic biomarkers that are used in machine learning algorithms to predict the patient clinical outcome. Two distinct phenotypes emerged from the analysis that correlate with patient drug resistance or sensitivity. Cross validation of the algorithms perform with an accuracy of 90% in the prediction of dogs that will respond to treatment. Biodynamic imaging has the potential to help select chemotherapy for personalized cancer care.

Conference Presentation

Citation Download Citation

H. Choi, J. Turek, Z. Li, M. Childress, and D. Nolte "Biodynamic imaging of therapeutic efficacy for canine B-cell lymphoma: preclinical trial results", Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 1049304 (13 February 2018); https://doi.org/10.1117/12.2291061

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