A novel small molecule mediate 18F-FDG excited fluorescence molecular imaging

Zeyu Zhang; Hongbo Guo; Zhenhua Hu; Jie Tian

doi:10.1117/12.2291300

20 February 2018 A novel small molecule mediate ¹⁸F-FDG excited fluorescence molecular imaging

Zeyu Zhang, Hongbo Guo, Zhenhua Hu, Jie Tian

Proceedings Volume 10497, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI; 1049705 (2018) https://doi.org/10.1117/12.2291300
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Fluorescence molecular imaging (FMI) has been widely used in many medical fields with small molecule indocyanine green (ICG). However, low signal-background ratio and limited specificity to tumor remain big challenges for FMI. In this study, a novel excitation strategy is proposed on the basis of clinical approved ICG and ¹⁸F-FDG. A series of in vitro experiments are designed to reveal the mechanism and results show obvious decreasing of ICG fluorescence intensity with the increasing distance to excitation source. Meanwhile, the ICG fluorescence intensity is proportional to the activity of radiopharmaceutical. Results from different respects illustrate the promising of this proposed excitation strategy.

Conference Presentation

Citation Download Citation

Zeyu Zhang, Hongbo Guo, Zhenhua Hu, and Jie Tian "A novel small molecule mediate ¹⁸F-FDG excited fluorescence molecular imaging", Proc. SPIE 10497, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI, 1049705 (20 February 2018); https://doi.org/10.1117/12.2291300

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available