Retinal phantom based on microfluidic channels for optical coherence tomography angiography (Conference Presentation)

Sang-Won Lee; Hyunji Lee; Il Doh; Nafra Mohamad Samiudin; Su Min Han

doi:10.1117/12.2511034

4 March 2019 Retinal phantom based on microfluidic channels for optical coherence tomography angiography (Conference Presentation)

Sang-Won Lee, Hyunji Lee, Il Doh, Nafra Mohamad Samiudin, Su Min Han

Author Affiliations +

Proceedings Volume 10870, Design and Quality for Biomedical Technologies XII; 108700R (2019) https://doi.org/10.1117/12.2511034
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Optical coherence tomography (OCT) is one of useful diagnostic devices for retinal diseases. Recently, optical coherence tomography based angiography (OCTA) extends the OCT applications from structural images to functional images by enabling blood vessel networks mapping. As the use of OCT and OCTA increases in ophthalmology, it is necessary to develop retinal phantoms for performance evaluation of clinical OCT devices for retinal imaging. In this study, we have developed a retinal layer-mimicking phantom including microfluidic channels to assess OCT and OCTA image quality and to evaluate software accuracy. The phantom is constructed of thin scattering films based on polydimethylsiloxane (PDMS) and titanium dioxide (TiO2) powder. We adjusted TiO2 particle concentration in PDMS for matching intensity of retinal OCT images. Particles were well dispersed throughout PDMS using a probe tip sonicator. Mixed PDMSs were carried out spin coating on a glass slide to make thin films. Before spin coating, silane was applied to the glass substrate to provide a hydrophobic coating for easily removing of cured PDMS. After spinning, thin filmed PDMSs were cured. Microfluidic channels were also made with PDMSs mixed with TiO2 powder, and were designed with sizes of 50 um, 100 um, and 200 um. thin films of cured PDMS were stacked on microfluidic channels. We used diluted dye liquids containing microbeads to occur optically scattered liquid flow like blood vessel. Dye liquids containing microbeads were flowed into an inlet port of the channel through a syringe pump Finally, we successfully obtained cross-sectional volumetric OCT and OCTA images of completed retinal phantom using lab-made OCT system and clinical OCT system.

Conference Presentation

Citation Download Citation

Sang-Won Lee, Hyunji Lee, Il Doh, Nafra Mohamad Samiudin, and Su Min Han "Retinal phantom based on microfluidic channels for optical coherence tomography angiography (Conference Presentation)", Proc. SPIE 10870, Design and Quality for Biomedical Technologies XII, 108700R (4 March 2019); https://doi.org/10.1117/12.2511034

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Optical coherence tomography

Microfluidics

Angiography

Thin films

Titanium dioxide

Coating

Liquids

Show All Keywords

Keywords/Phrases

Search In:

Publication Years