Vascular mesh and diffusive bells: 2D modeling of blood-brain barrier leakage

Kristina V. Rogatina; Anton A. Namykin; Dmitry E. Postnov

doi:10.1117/12.2523914

3 June 2019 Vascular mesh and diffusive bells: 2D modeling of blood-brain barrier leakage

Kristina V. Rogatina, Anton A. Namykin, Dmitry E. Postnov

Author Affiliations +

Proceedings Volume 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions; 1106712 (2019) https://doi.org/10.1117/12.2523914
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

Fluorescent methods are widely used in studies of the physiology of the brain in general, and in the analysis of the degree of permeability of the blood-brain barrier (BBB) in particular. As recent experimental data show, the spatial patterns of the BBB opening, on the one hand, observed for the whole brain, and on the other, they can be highly localized if one track their from the very beginning. We consider the issues related to image analysis from the point of view of the classification of flowrescent objects, and also propose a technology for simulating BBB leakage based on layer-by-layer modeling of the diffusion process in a heterogeneous spatial template created directly from experimental data.

Citation Download Citation

Kristina V. Rogatina, Anton A. Namykin, and Dmitry E. Postnov "Vascular mesh and diffusive bells: 2D modeling of blood-brain barrier leakage", Proc. SPIE 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 1106712 (3 June 2019); https://doi.org/10.1117/12.2523914

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