Smartphone-based epifluorescence microscope for fresh tissue imaging

Wenbin Zhu; Giacomo Pirovano; Cheng Gong; Nachiket Kulkarni; Christopher David Nguyen; Christian Brand; Thomas Reiner; Dongkyun Kang

doi:10.1117/12.2526857

22 July 2019 Smartphone-based epifluorescence microscope for fresh tissue imaging

Wenbin Zhu, Giacomo Pirovano, Cheng Gong, Nachiket Kulkarni, Christopher David Nguyen, Christian Brand, Thomas Reiner, Dongkyun Kang

Author Affiliations +

Proceedings Volume 11075, Novel Biophotonics Techniques and Applications V; 110750B (2019) https://doi.org/10.1117/12.2526857
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

We developed a smartphone-based epifluorescence microscope for fresh tissue imaging. The smartphone microscope optics was optimally designed to achieve similar resolution (0.56 μm) and FOV (520 μm) as the bench 40x microscope, commonly used during the histopathologic analysis. Preliminary images obtained from an excised human pancreatic tissue stained with a rapid staining fluorescence dye (PARPi-FL) clearly visualized individual tumor cells.

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Wenbin Zhu, Giacomo Pirovano, Cheng Gong, Nachiket Kulkarni, Christopher David Nguyen, Christian Brand, Thomas Reiner, and Dongkyun Kang "Smartphone-based epifluorescence microscope for fresh tissue imaging", Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110750B (22 July 2019); https://doi.org/10.1117/12.2526857

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KEYWORDS

Microscopes

Tissues

Microscopy

Tissue optics

Tumors

Biopsy

Point-of-care devices

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