Integrated optofluidics: label-free isolation of nanoscale bioparticles from heterogenous samples (Conference Presentation)

Xiangchao Zhu; Ahmet Cicek; Yixiang Li; Ahmet Ali Yanik

doi:10.1117/12.2547106

9 March 2020 Integrated optofluidics: label-free isolation of nanoscale bioparticles from heterogenous samples (Conference Presentation)

Xiangchao Zhu, Ahmet Cicek, Yixiang Li, Ahmet Ali Yanik

Author Affiliations +

Proceedings Volume 11235, Microfluidics, BioMEMS, and Medical Microsystems XVIII; 112350T (2020) https://doi.org/10.1117/12.2547106
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We introduce Optofluidic PlasmonIC (OPtIC) microlenses to overcome the shortcomings of existing optical chromatography techniques by eliminating the need for sophisticated instrumentation and pre- cise alignment requirements. Our sub-wavelength thick (~200 nm thick) OPtIC microlenses offer objective-free focusing and self-alignment of optical and fluidic drag forces and present a facile platform for selective separation of exosome size bioparticles. By allowing direct coupling of collimated broadband light to realize strong optical scattering forces at a focal point, extremely small footprint (4 μm × 4 μm) OPtIC microlenses open the door for drastically multiplexed optical chromatography and high-throughput sample processing capability.

Conference Presentation

Citation Download Citation

Xiangchao Zhu, Ahmet Cicek, Yixiang Li, and Ahmet Ali Yanik "Integrated optofluidics: label-free isolation of nanoscale bioparticles from heterogenous samples (Conference Presentation)", Proc. SPIE 11235, Microfluidics, BioMEMS, and Medical Microsystems XVIII, 112350T (9 March 2020); https://doi.org/10.1117/12.2547106

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