Photoacoustic monitoring of drug release from PLGA nanocarriers for tumor treatment (Conference Presentation)

Jeanne Lemaster

doi:10.1117/12.2546572

10 March 2020 Photoacoustic monitoring of drug release from PLGA nanocarriers for tumor treatment (Conference Presentation)

Jeanne Lemaster

Author Affiliations +

Proceedings Volume 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII; 112540A (2020) https://doi.org/10.1117/12.2546572
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

This study details the synthesis and time release properties of a paclitaxel-methylene blue drug incapsulated in a PLGA nanoparticle. The most important finding is that a redox switch of the methylene blue between the leuco and oxidized forms causes a change from photoacoustically silent to photoacoustically active states which was used to monitor drug release in vivo. We used this photoacoustic signal change to monitor drug release from paclitaxel-methylene blue encapsulated in PLGA in a murine model.

Conference Presentation

Citation Download Citation

Jeanne Lemaster "Photoacoustic monitoring of drug release from PLGA nanocarriers for tumor treatment (Conference Presentation)", Proc. SPIE 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII, 112540A (10 March 2020); https://doi.org/10.1117/12.2546572

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