The Role Of FT-IR In The Identification Of Domoic Acid, A New Shellfish Toxin

Michael Falk

doi:10.1117/12.969641

1 December 1989 The Role Of FT-IR In The Identification Of Domoic Acid, A New Shellfish Toxin

Michael Falk

Proceedings Volume 1145, 7th Intl Conf on Fourier Transform Spectroscopy; (1989) https://doi.org/10.1117/12.969641
Event: Seventh International Conference on Fourier and Computerized Infrared Spectroscopy, 1989, Fairfax, VA, United States

Abstract

A brief but serious outbreak of poisoning by mussels occurred in Canada in December 1987. In a round-the-clock effort, the toxin that caused this outbreak was isolated in our laboratory and identified as domoic acid, a naturally-occurring substance that had not previously been reported to cause human poisoning. The identification of the toxin was achieved by the concerted use of spectroscopic methods, among them micro-FT-IR spectroscopy. The use of the FT-IR microscope allowed high-quality infrared spectra to be obtained on sub-microgram quantities of the early isolates of the toxin. The microscopic method had an additional advantage in that it enabled us to carry out a rough but rapid separation of the compound of interest from admixtures of unrelated substances by recording the spectra of a gradually dried out drop of solution on a microscope plate. Following the positive identification of the toxin as domoic acid, a detailed spectroscopic study was made of this important molecule in its several isomeric forms.

Citation Download Citation

Michael Falk "The Role Of FT-IR In The Identification Of Domoic Acid, A New Shellfish Toxin", Proc. SPIE 1145, 7th Intl Conf on Fourier Transform Spectroscopy, (1 December 1989); https://doi.org/10.1117/12.969641

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