CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 11469 > Article
Presentation
20 August 2020 Delayed correlation analyses are sensitive to functional network changes in Parkinson’s disease
Mite Mijalkov, Joana B. Pereira
Author Affiliations +
Proceedings Volume 11469, Emerging Topics in Artificial Intelligence 2020; 114690X (2020) https://doi.org/10.1117/12.2569946
Event: SPIE Nanoscience + Engineering, 2020, Online Only
Abstract
Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by motor and non-motor deficits. Several studies found changes in the topological organization of functional networks in PD built by methods that assume a simultaneous and undirected activation between brain areas. However, changes associated with PD may result in a specific alteration of the directed activity patterns between brain areas. In this study, we propose a new method to build directed functional networks in patients with PD. We show that the directed network analyses can identify widespread functional brain changes in PD characterized by higher efficiency, clustering and transitivity as well as lower modularity. Some of these network measures were associated with motor, executive and memory deficits, suggesting they are sensitive to clinical impairment in PD. Altogether our findings suggest that the directional flow in brain activation could be used as an indicator of PD-related neuronal changes.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Mite Mijalkov and Joana B. Pereira "Delayed correlation analyses are sensitive to functional network changes in Parkinson’s disease", Proc. SPIE 11469, Emerging Topics in Artificial Intelligence 2020, 114690X (20 August 2020); https://doi.org/10.1117/12.2569946
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Brain
Control systems
Parkinson's disease
Brain activation
Magnetic resonance imaging
Network security
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top