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Photoacoustic image has recently emerged as a promising imaging modality for imaging prostate cancer.This paper made a qualitative analysis of photoacoustic signal generation according to the relationship between photoacoustic signal and the changes of light absorption energy. A 3D prostate optical model embedded tumors was established based on human prostate morphology through programming. The light energy distribution in the prostate with pulsed light was obtained by use of Monte Carlo method. The time-dependent spatial distribution of light absorption energy was obtained for photoacoustic signal generation at different positions. Comparison has been made between each other. Meanwhile, photoacoustic imaging experiment has been carried out. Our work might also be helpful for future simulation of photoacoustic imaging and investigation of detection sensitivity and imaging depth of photoacoustic imaging system.
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Dongqing Peng, Zhigao Liu, Huizhen Xu, Lili Zhu, Hui Li, "Simulation investigation of photoacoustic signal generation in the prostate tissue," Proc. SPIE 11553, Optics in Health Care and Biomedical Optics X, 115531J (10 October 2020); https://doi.org/10.1117/12.2572790