Improved biomedical imaging over a wide spectral range from UV to THz towards multimodality

Luís M. Oliveira; Kirill I. Zaytsev; Valery V. Tuchin

doi:10.1117/12.2584999

28 October 2020 Improved biomedical imaging over a wide spectral range from UV to THz towards multimodality

Luís M. Oliveira, Kirill I. Zaytsev, Valery V. Tuchin

Author Affiliations +

Proceedings Volume 11585, Biophotonics—Riga 2020; 1158503 (2020) https://doi.org/10.1117/12.2584999
Event: Third International Conference Biophotonics Riga 2020, 2020, Riga, Latvia

Abstract

The concept of ‘tissue optical windows’ and method of optical clearing (OC) based on controllable and reversible modification of tissue optical properties by their soaking with a biocompatible optical clearing agent (OCA) are prsented. Fundamentals and major mechanisms of OC allowing one to enhance optical imaging facilities and laser treatment efficiency of living tissues are described. Perspectives of immersion optical clearing/contrasting technique aiming to enhance optical imaging of living tissues by using different imaging modalities working in the ultra-broad wavelength range from deep UV to terahertz waves are discussed. It demonstrated that immersion OC method can be applied to evaluate the characteristic diffusion properties of water and OCA in various tissues and even discriminate between the mobile water content in normal and pathological tissues.

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Luís M. Oliveira, Kirill I. Zaytsev, and Valery V. Tuchin "Improved biomedical imaging over a wide spectral range from UV to THz towards multimodality", Proc. SPIE 11585, Biophotonics—Riga 2020, 1158503 (28 October 2020); https://doi.org/10.1117/12.2584999

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