The ability to organize nano-components into the desired architectures with targeted properties can enable a broad range of nanotechnological applications, from energy materials to information processing. However, we are currently lacking an adaptable and broadly applicable methodology for the bottom-up 3D nanofabrication of desired nanoscale structures. I will discuss our efforts on establishing a versatile fabrication platform based on the molecularly programmable assembly for the formation of targeted architectures from inorganic and biomolecular nano-components. The recent advances on building periodic and hierarchical organizations, frameworks and arbitrary designed architectures using DNA-encoded interactions and DNA topologies will be presented. I will demonstrate how these assembly approaches can be used for a fabrication of nanomaterials with novel optical, mechanical, and catalytic functions.
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