Quantitative light scattering analysis for the characterization of layers of the retina using optical coherence tomography

Taylor M. Cannon; Brett E. Bouma; Néstor Uribe-Patarroyo

doi:10.1117/12.2577675

5 March 2021 Quantitative light scattering analysis for the characterization of layers of the retina using optical coherence tomography

Taylor M. Cannon, Brett E. Bouma, Néstor Uribe-Patarroyo

Author Affiliations +

Proceedings Volume 11623, Ophthalmic Technologies XXXI; 116231A (2021) https://doi.org/10.1117/12.2577675
Event: SPIE BiOS, 2021, Online Only

Abstract

Conventional optical coherence tomography (OCT) is unable to visualize the earliest microstructural changes that accompany retinal dysfunction and pathology, delaying diagnoses in diseases such as glaucoma. We present methods for analyzing light scattering behavior using OCT to report microscopic structural changes using our layer-based, depth-resolved attenuation coefficient, and layer-resolved backscattering fraction. These quantitative scattering parameters are sensitive to sub-resolution status of pathologically relevant features such as constituent cells, intracellular components, and fiber organization. Preliminary results show additional feature contrast in a healthy subject, and we look forward to exploring the future clinical potential of these methods to enable earlier diagnoses.

Conference Presentation

Citation Download Citation

Taylor M. Cannon, Brett E. Bouma, and Néstor Uribe-Patarroyo "Quantitative light scattering analysis for the characterization of layers of the retina using optical coherence tomography", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116231A (5 March 2021); https://doi.org/10.1117/12.2577675

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