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5 March 2021 An on-chip biosensor based on supercritical angle fluorescence
Finub James Shirley, Tim Steylaerts, Pieter Neutens, Pol Van Dorpe
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Proceedings Volume 11626, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2021; 116260H (2021) https://doi.org/10.1117/12.2578306
Event: SPIE BiOS, 2021, Online Only
Abstract
Supercritical angle fluorescence (SAF) is a surface sensitive detection mechanism that has been used to perform rapid, sensitive detection of biomolecules. However, the SAF biosensors that have been demonstrated so far have been either bulky and expensive or small and affordable while sacrificing on sensitivity . We present a novel interference based SAF biosensor technology that has the potential to be fast, small, inexpensive and mass manufacturable while being as sensitive as the current gold standard. This technology can therefore create biosensors in a wide range of form factors, from large, complex high multiplex devices to small handheld point of care solutions.
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Finub James Shirley, Tim Steylaerts, Pieter Neutens, and Pol Van Dorpe "An on-chip biosensor based on supercritical angle fluorescence", Proc. SPIE 11626, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2021, 116260H (5 March 2021); https://doi.org/10.1117/12.2578306
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KEYWORDS
Biosensors
Luminescence
Biological research
Photons
Point-of-care devices
Proteins
Quartz
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