Polarization enhanced spectral contrast for optical coherence tomography

Pelham Keahey; Peng Si; Shangjie Yu; Taylor Cannon; Martin Villiger; Adam de la Zerda; Brett Bouma

doi:10.1117/12.2577761

5 March 2021 Polarization enhanced spectral contrast for optical coherence tomography

Pelham Keahey, Peng Si, Shangjie Yu, Taylor Cannon, Martin Villiger, Adam de la Zerda, Brett Bouma

Author Affiliations +

Proceedings Volume 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV; 1163013 (2021) https://doi.org/10.1117/12.2577761
Event: SPIE BiOS, 2021, Online Only

Abstract

Polarization Sensitive Optical Coherence Tomography (PS-OCT) measures the polarization state of backscattered light and provides information regarding its retardation and depolarization caused by propagation through tissue microstructure. Developing molecular contrast agents could enhance the utility of OCT for physiological, cellular, and molecular imaging. In this study, we characterize for the first time the depolarization signature of gold nanobipyramids (GNBPs) and demonstrate how depolarization can be used to enhance Spectral Contrast OCT based detection of GNBPs for multiplexed contrast agent detection.

Conference Presentation

Citation Download Citation

Pelham Keahey, Peng Si, Shangjie Yu, Taylor Cannon, Martin Villiger, Adam de la Zerda, and Brett Bouma "Polarization enhanced spectral contrast for optical coherence tomography", Proc. SPIE 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, 1163013 (5 March 2021); https://doi.org/10.1117/12.2577761

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