Quantitative scattering parameters measured with optical coherence tomography are sensitive to microstructural tissue pathologies

Taylor M. Cannon; Martin Villiger; Brett E. Bouma; Néstor Uribe-Patarroyo

doi:10.1117/12.2577858

5 March 2021 Quantitative scattering parameters measured with optical coherence tomography are sensitive to microstructural tissue pathologies

Taylor M. Cannon, Martin Villiger, Brett E. Bouma, Néstor Uribe-Patarroyo

Author Affiliations +

Proceedings Volume 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV; 116301D (2021) https://doi.org/10.1117/12.2577858
Event: SPIE BiOS, 2021, Online Only

Abstract

Structural optical coherence tomography (OCT) images stand to benefit from increased contrast. The OCT attenuation coefficient has previously been explored as a means of additional contrast, as it is sensitive to sub-resolution physical properties of the sample, which could be advantageous in differentiating various tissue pathologies. We have developed a new method for OCT attenuation coefficient quantification which combines advantages of prior methods of exponential fitting and the depth-resolved algorithm, and additionally calculates a layer-resolved backscattering fraction. Together, these quantitative scattering parameters provide enhanced accuracy and contrast that could aid in image interpretation in clinical applications such as intravascular OCT.

Conference Presentation

Citation Download Citation

Taylor M. Cannon, Martin Villiger, Brett E. Bouma, and Néstor Uribe-Patarroyo "Quantitative scattering parameters measured with optical coherence tomography are sensitive to microstructural tissue pathologies", Proc. SPIE 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, 116301D (5 March 2021); https://doi.org/10.1117/12.2577858

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