Multimodal optical assessment of breast tumor aggressiveness and progression in murine models

Bin Deng; Ailis Muldoon; Rahul Pal; Alana W. Ross; Pamela Pantazopoulos; Zdravka O. Medarova; Anand T. N. Kumar; Stefan A. Carp

doi:10.1117/12.2577699

5 March 2021 Multimodal optical assessment of breast tumor aggressiveness and progression in murine models

Bin Deng, Ailis Muldoon, Rahul Pal, Alana W. Ross, Pamela Pantazopoulos, Zdravka O. Medarova, Anand T. N. Kumar, Stefan A. Carp

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Proceedings Volume 11634, Multimodal Biomedical Imaging XVI; 116340B (2021) https://doi.org/10.1117/12.2577699
Event: SPIE BiOS, 2021, Online Only

Abstract

Breast cancer is a highly heterogeneous disease comprising a variety of genotypes and phenotypes of varying levels of aggressiveness. This presents significant challenges to clinical management of early-stage cancers. In this paper, we describe the use of multimodal optical technologies including near-infrared (NIR) spectroscopy, diffuse correlation spectroscopy (DCS) and indocyanine green (ICG) fluorescence imaging to evaluate the aggressiveness and progression of two patient-derived xenograft models of human breast cancer. Optical markers reveal distinctive features between low- and high-aggressiveness tumors that could potentially be translated for clinical use.

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Bin Deng, Ailis Muldoon, Rahul Pal, Alana W. Ross, Pamela Pantazopoulos, Zdravka O. Medarova, Anand T. N. Kumar, and Stefan A. Carp "Multimodal optical assessment of breast tumor aggressiveness and progression in murine models", Proc. SPIE 11634, Multimodal Biomedical Imaging XVI, 116340B (5 March 2021); https://doi.org/10.1117/12.2577699

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KEYWORDS

Tumors

Breast

Breast cancer

Near infrared spectroscopy

Fluorescence spectroscopy

Imaging spectroscopy

Indocyanine green

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