Sensitivity of FD-NIRS dual slopes to absorption perturbations in layered media

Angelo Sassaroli; Giles Blaney; Thao Pham; Cristianne Fernandez; Sergio Fantini

doi:10.1117/12.2577633

5 March 2021 Sensitivity of FD-NIRS dual slopes to absorption perturbations in layered media

Angelo Sassaroli, Giles Blaney, Thao Pham, Cristianne Fernandez, Sergio Fantini

Author Affiliations +

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116390S (2021) https://doi.org/10.1117/12.2577633
Event: SPIE BiOS, 2021, Online Only

Abstract

In this work we provide some examples of sensitivity of the dual slope method to localized absorption changes in the layered geometry. Reasonably, this model geometry better represents many types of tissue. The sensitivity is shown in a two- and three-layer geometry for alternating current (AC) and phase data for both point-like and layered-like absorption perturbations. Contrary to the homogeneous medium geometry, where the ratio of deep to superficial tissue sensitivity of phase is always greater than that of AC, this is not always the case in the layered geometry. Therefore, depending on the targeted tissue, subject and protocol, in some cases it might be preferable to use AC dual-slopes, whereas in other cases phase dual-slope may be a better choice.

Conference Presentation

Citation Download Citation

Angelo Sassaroli, Giles Blaney, Thao Pham, Cristianne Fernandez, and Sergio Fantini "Sensitivity of FD-NIRS dual slopes to absorption perturbations in layered media", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116390S (5 March 2021); https://doi.org/10.1117/12.2577633

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