Molecular spectrometry of the blood of breast cancer patients as a preliminary stage of further molecular genetic screening

Olexander Peresunko; Tatiana Kruk; Ion Gruia; Sergey Yermolenko; Maria Ju. Gruia

doi:10.1117/12.2571214

31 December 2020 Molecular spectrometry of the blood of breast cancer patients as a preliminary stage of further molecular genetic screening

Olexander Peresunko, Tatiana Kruk, Ion Gruia, Sergey Yermolenko, Maria Ju. Gruia

Author Affiliations +

Proceedings Volume 11718, Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies X; 117181K (2020) https://doi.org/10.1117/12.2571214
Event: Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies 2020, 2020, Online Only

Abstract

The aim of this paper is to study BRCA1 - 185delAg and 5382insC gene mutations in breast cancer patients and their relatives to identify new directions for the prevention, diagnosis and treatment of breast cancer. As diagnostic methods have been used ultraviolet spectrometry samples of blood plasma in the liquid state, infrared spectroscopy middle range (2,5 - 25 microns) dry residue of plasma polarization and laser diagnostic technique of thin histological sections of biological tissues. Obtained results showed that the use of spectrophotometry in the range of 1000-3000 cm-1 allowed to establish quantitative parameters of the plasma absorption rate of blood of patients in the third group in different ranges, which would allow in the future to conduct an express analysis of the patient's condition (procedure screening) for further molecular-genetic typing on BRCA I and II.

Citation Download Citation

Olexander Peresunko, Tatiana Kruk, Ion Gruia, Sergey Yermolenko, and Maria Ju. Gruia "Molecular spectrometry of the blood of breast cancer patients as a preliminary stage of further molecular genetic screening", Proc. SPIE 11718, Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies X, 117181K (31 December 2020); https://doi.org/10.1117/12.2571214

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