Synthesis spectroscopic investigation and pharmacological evaluation of metal complex containing O, S donor ligand

Bushra Shakoor; Faiza Asghar

doi:10.1117/12.2600495

1 July 2021 Synthesis spectroscopic investigation and pharmacological evaluation of metal complex containing O, S donor ligand

Bushra Shakoor, Faiza Asghar

Author Affiliations +

Proceedings Volume 11877, Second iiScience International Conference 2021: Recent Advances in Photonics and Physical Sciences; 1187709 (2021) https://doi.org/10.1117/12.2600495
Event: 2nd iiScience International Conference 2021: Recent Advances in Photonics and Physical Sciences, 2021, Faisalabad, Pakistan

Abstract

Thiourea, an O and S containing compound, is an important reagent in organic synthesis, used as a source of sulphides, acts as a reactant in synthesis of many heterocyclic compounds. The presence of O and S donor atoms offers a multitude of bonding possibilities, enables them to act as versatile ligands and form stable complexes. The purpose of this research work was to synthesize the transition metal complex of acyl derivative possessing oxygen and sulfur donor atoms that can act as efficient antibacterial and antifungal agents. An O, S donor ligand was prepared by the reaction between isothiocyanate and substituted amine. Metal complex of this bidentate ligand was synthesized by the reaction between metal salt and ligand. Zinc based thiourea such as: 3-(4-bromobenzoyl)-1-ethyl-1-(4-fluorophenyl) thiourea display a broad spectrum of biological applications. Acyl derivative and its complex was structurally analyzed by Fourier transform infrared spectroscopy and elemental analysis. Biological activity was checked by preparing different culture media.

Citation Download Citation

Bushra Shakoor and Faiza Asghar "Synthesis spectroscopic investigation and pharmacological evaluation of metal complex containing O, S donor ligand", Proc. SPIE 11877, Second iiScience International Conference 2021: Recent Advances in Photonics and Physical Sciences, 1187709 (1 July 2021); https://doi.org/10.1117/12.2600495

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