Reliability of handheld laser speckle contrast perfusion imaging demonstrated in psoriasis lesions

Ata Chizari; Mirjam J. Schaap; Tom Knop; Marieke M. B. Seyger; Wiendelt Steenbergen

doi:10.1117/12.2608663

3 March 2022 Reliability of handheld laser speckle contrast perfusion imaging demonstrated in psoriasis lesions

Ata Chizari, Mirjam J. Schaap, Tom Knop, Marieke M. B. Seyger, Wiendelt Steenbergen

Proceedings Volume 11934, Photonics in Dermatology and Plastic Surgery 2022; 119340A (2022) https://doi.org/10.1117/12.2608663
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We assessed the reliability of handheld laser speckle contrast perfusion imaging by evaluating mounted/handheld measurement pairs operated on psoriasis lesions in three steps. First, we made a denoised perfusion map per measurement based on spatial alignment of raw speckle frames and temporal averaging of perfusion frames. Second, we used the measured on-surface speed information to compensate the movement-induced perfusion by extrapolation of the local perfusion values to the value corresponds to zero on-surface speed. Third, we compared mounted/handheld measurement pairs based on perfusion inhomogeneity and increased perilesional perfusion criteria independent of the movement artefact compensation mentioned in the second step. We conclude that after proper post-processing, handheld LSCI measurements can be as reliable as mounted measurements in terms of geometrical distorting, but with challenges to be overcome for correcting perfusion values.

Conference Presentation

Citation Download Citation

Ata Chizari, Mirjam J. Schaap, Tom Knop, Marieke M. B. Seyger, and Wiendelt Steenbergen "Reliability of handheld laser speckle contrast perfusion imaging demonstrated in psoriasis lesions", Proc. SPIE 11934, Photonics in Dermatology and Plastic Surgery 2022, 119340A (3 March 2022); https://doi.org/10.1117/12.2608663

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