Accurate measurement of SpO2 and dermal skin hydration using a wearable miniaturized spectrometer

R. Van Beers; M. Jacobs; A. Borgoo; M. Hornikx; S. Janssens; W. van der Tempel; J. Borremans

doi:10.1117/12.2607346

2 March 2022 Accurate measurement of SpO₂ and dermal skin hydration using a wearable miniaturized spectrometer

R. Van Beers, M. Jacobs, A. Borgoo, M. Hornikx, S. Janssens, W. van der Tempel, J. Borremans

Proceedings Volume 11956, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables III; 1195602 (2022) https://doi.org/10.1117/12.2607346
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We present the performance of a CMOS miniaturized (4mm x 3.2mm x 3.3mm) spectrometer for two specific wearable health applications: reflective medically-accurate SpO₂ and dermal H₂O measurement for preventive health and remote follow-up use cases. The spectrometer has been manufactured using a monolithically integrated filter process, enabling low-cost, low-power, miniature and mass-producible spectral sensors. Accurate biomarker models can be built using continuous on-skin hyperspectral tissue and PPG data. A deoxygenation trial on 17 healthy volunteers was conducted using the wrist-worn spectrometer in the 650-900nm wavelength range. Using partial least squares (PLS) modeling, a model was built to correlate the obtained spectral PPG data to SpO₂ data from a reference finger clip (Nonin 8000A). In the tested range between 87% and 100% SpO₂, an RMSEP of 1.86%SpO₂ has been obtained on a separate test set, well within the 3.5% requirement of the FDA. For dermal skin hydration, a study on 29 volunteers (including 4 patients with congestive heart failure (CHF) and fluid retention in legs) was conducted with the spectrometer in the 750-1050 nm range. A spectroscopic model was compared with a lymph scanner as gold standard measuring localized percentage water content (PWC), yielding a decent prediction accuracy of 3.3% RMSE, while correctly identifying the patients with CHF. We demonstrated the viability of a miniaturized spectrometer for wearable skin biomarker measurements. This solution has the potential to detect other tissue biomarkers such as SpCO or StO₂, or to read subdermal markers such as hydrogels for glucose or lactate detection.

Conference Presentation

Citation Download Citation

R. Van Beers, M. Jacobs, A. Borgoo, M. Hornikx, S. Janssens, W. van der Tempel, and J. Borremans "Accurate measurement of SpO₂ and dermal skin hydration using a wearable miniaturized spectrometer", Proc. SPIE 11956, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables III, 1195602 (2 March 2022); https://doi.org/10.1117/12.2607346

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