Lock-in amplified differential phase contrast

Chiara Bonati; Damien Loterie; Timothé Laforest; Christophe Moser

doi:10.1117/12.2607759

2 March 2022 Lock-in amplified differential phase contrast

Chiara Bonati, Damien Loterie, Timothé Laforest, Christophe Moser

Proceedings Volume 11970, Quantitative Phase Imaging VIII; 1197005 (2022) https://doi.org/10.1117/12.2607759
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We introduce a lock-in method to increase the phase contrast in incoherent Differential Phase Contrast (DPC) imaging. The use of a smart pixel detector with in-pixel signal demodulation, paired with synchronized illumination, provides the basis of a bit-efficient approach to DPC. The experiments show an increased sensitivity by a factor of 8, for equivalent standard DPC measurements; single-shot sensitivity of 0.7 mrad at a frame rate of 1400 fps is demonstrated. This new approach may open the way for the use of incoherent phase microscopy in biological applications where extreme phase sensitivity and millisecond response time is required.

Conference Presentation

Citation Download Citation

Chiara Bonati, Damien Loterie, Timothé Laforest, and Christophe Moser "Lock-in amplified differential phase contrast", Proc. SPIE 11970, Quantitative Phase Imaging VIII, 1197005 (2 March 2022); https://doi.org/10.1117/12.2607759

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