Factors of importance in the generation of singlet oxygen during photodynamic treatment of tumors

John G. Parker

doi:10.1117/12.17647

1 July 1990 Factors of importance in the generation of singlet oxygen during photodynamic treatment of tumors

John G. Parker

Proceedings Volume 1203, Photodynamic Therapy: Mechanisms II; (1990) https://doi.org/10.1117/12.17647
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

Photodynamic therapy (PDT), a relatively new treatment for cancer, has evolved from the investigational stage and is now being evaluated clinically for certain cancer types under FDA-approved protocols. Results obtained to date indicate the treatment to be promising, however, not without limitations. This therapy involves the cooperative action of an injectable tumor-specific sensitizer and light, usually provided by the output of a laser. The general view, supported by a large body of in vitro data, is that the most important agent of tumor destruction is electronically excited oxygen (singlet oxygen) generated by a favored energy transfer from the optically excited sensitizer to ambient ground state oxygen. It is clear, therefore, that to understand the limitations of PDT in cancer treatment one has to fully understand the nature of singlet oxygen (102) interactions in the in vivo environment. This, of course, first requires an appropriate means for 102 detection and measurement. The recent demonstration in this laboratory that in vivo 102 detection during photodynamic treatment of tumors is indeed possible opens up this possibility.

Citation Download Citation

John G. Parker "Factors of importance in the generation of singlet oxygen during photodynamic treatment of tumors", Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); https://doi.org/10.1117/12.17647

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