Chemometrics-assisted spectrophotometric determination of synthetic food colorants in "Strepsils" lozenges

Dmitriy Silaev; Tatiana Yu. Rusanova; Yuliya Fomina; Nataliya Shestopalova

doi:10.1117/12.2625770

29 April 2022 Chemometrics-assisted spectrophotometric determination of synthetic food colorants in "Strepsils" lozenges

Dmitriy Silaev, Tatiana Yu. Rusanova, Yuliya Fomina, Nataliya Shestopalova

Author Affiliations +

Proceedings Volume 12192, Optical Technologies for Biology and Medicine; 1219209 (2022) https://doi.org/10.1117/12.2625770
Event: XXV Annual Conference Saratov Fall Meeting 2021; and IX Symposium on Optics and Biophotonics, 2021, Saratov, Russian Federation

Abstract

Medications with an antiseptic effect for the treatment of pain in the mouth and throat are especially relevant in the autumn-winter period. The composition of these drugs, in addition to the active substances with antiseptic action, also include auxiliary substances, for example, synthetic food colorants (SFC). The need to control the amount of SFC consumed is an important task, since exceeding the permissible daily intake can lead to allergic reactions, hyperactivity in children. Two chemometric methods applied were partial least squares (PLS) and principal component regression (PCR). These approaches were used to quantify the colorants in model colorants solutions and "Strepsils" lozenges aqueous solution based on information included in the visual absorption spectra. The calibration PLS and PCR models were evaluated by internal validation (prediction of compounds in its own designed training set of calibration) and by external validation over pharmaceutical preparation. The accuracy of the methods was evaluated through the root mean square error of prediction (RMSEP). The results of PLS and PCR methods were compared and the best models for the system were obtained with PCR. Ultimately, a method was developed for the chemometric-assisted spectrophotometric determination of E110 in the presence of E124 in the "Strepsils" tablets, which is characterized by simplicity and rapidity.

Citation Download Citation

Dmitriy Silaev, Tatiana Yu. Rusanova, Yuliya Fomina, and Nataliya Shestopalova "Chemometrics-assisted spectrophotometric determination of synthetic food colorants in "Strepsils" lozenges", Proc. SPIE 12192, Optical Technologies for Biology and Medicine, 1219209 (29 April 2022); https://doi.org/10.1117/12.2625770

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KEYWORDS

Tablets

Chemometrics

Spectrophotometry

Calibration

Excel

Mouth

Throat

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