Super-resolution SERS spectral bioimaging

Zachary D. Schultz; Deben N. Shoup; Abigail E. Smith

doi:10.1117/12.2632824

3 October 2022 Super-resolution SERS spectral bioimaging

Zachary D. Schultz, Deben N. Shoup, Abigail E. Smith

Author Affiliations +

Proceedings Volume 12203, Enhanced Spectroscopies and Nanoimaging 2022; 1220304 (2022) https://doi.org/10.1117/12.2632824
Event: SPIE Nanoscience + Engineering, 2022, San Diego, California, United States

Abstract

Advances in nanotechnology enable the detection of trace molecules from the enhanced Raman signal generated at the surface of plasmonic nanoparticles. We have developed technology to enable super-resolution imaging of plasmonic nanoparticles, where the fluctuations in the surface enhanced Raman scattering (SERS) signal can be analyzed with localization microscopy techniques to provide nanometer spatial resolution of the emitting molecule’s location. Additional work now enables the super-resolved SERS image and the corresponding spectrum to be acquired simultaneously. Here we will discuss how this approach can be applied to provide new insights into biological cells.

Conference Presentation

Citation Download Citation

Zachary D. Schultz, Deben N. Shoup, and Abigail E. Smith "Super-resolution SERS spectral bioimaging", Proc. SPIE 12203, Enhanced Spectroscopies and Nanoimaging 2022, 1220304 (3 October 2022); https://doi.org/10.1117/12.2632824

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