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The presentation will address methodological aspects and limits of detection of confocal Raman spectroscopy for use in quantitative in vivo analysis of skin penetration and permeation of topically applied materials. The differences in penetration rate of skin at different anatomical locations will be illustrated as well as the effect of product formulation on the penetration of an active.
Gerwin J. Puppels,Peter J. Caspers,Tom Bakker Schut, andClaudio Nico
"Quantitative analysis of in vivo skin penetration by confocal Raman spectroscopy", Proc. SPIE 12357, Visualizing and Quantifying Drug Distribution in Tissue VII, 1235704 (17 March 2023); https://doi.org/10.1117/12.2651539
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Gerwin J. Puppels, Peter J. Caspers, Tom Bakker Schut, Claudio Nico, "Quantitative analysis of in vivo skin penetration by confocal Raman spectroscopy," Proc. SPIE 12357, Visualizing and Quantifying Drug Distribution in Tissue VII, 1235704 (17 March 2023); https://doi.org/10.1117/12.2651539