Risk prediction on orthopaedic trauma patients for fracture-associated infection using dynamic contrast enhanced-fluorescence imaging

Xinyue Han; Logan M. Bateman; Paul M. Werth; Shudong Jiang; I. Leah Gitajn; Jonathan Thomas Elliott

doi:10.1117/12.2650773

14 March 2023 Risk prediction on orthopaedic trauma patients for fracture-associated infection using dynamic contrast enhanced-fluorescence imaging

Xinyue Han, Logan M. Bateman, Paul M. Werth, Shudong Jiang, I. Leah Gitajn, Jonathan Thomas Elliott

Author Affiliations +

Proceedings Volume 12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; 123610A (2023) https://doi.org/10.1117/12.2650773
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Debridement of the surgical site during open fracture reduction and internal fixation is important for preventing surgical site infection; the risk of subsequent fracture-associated infection for a particular area of tissue is assessed by the surgeon based on multi-level variables, including demographics and laboratory results. Intraoperative fluorescence imaging can contribute additional information at a more localized level. Here we present a fluorescence-based predictive model using features from dynamic contrast enhanced-fluorescence imaging (DCE-FI), as well as patient-level variables associated with infection risk. Regions-of-interest were selected from thirty-eight enrolled open fracture patients. Spatial and kinetic features were extracted from DCE-FI, and combined with patient infection risk factor describing the possibility of getting surgical-site-infection. The model was evaluated for ability to predict composite outcome scores—intra-operative surgeon assessment coupled with post-operative confirmed infection outcome. This proposed model demonstrates high predictive performance with an accuracy of 0.86, evaluated with a cross-validation approach, and is a promising approach for early and quick identification of tissue prone to infection.

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Citation Download Citation

Xinyue Han, Logan M. Bateman, Paul M. Werth, Shudong Jiang, I. Leah Gitajn, and Jonathan Thomas Elliott "Risk prediction on orthopaedic trauma patients for fracture-associated infection using dynamic contrast enhanced-fluorescence imaging", Proc. SPIE 12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, 123610A (14 March 2023); https://doi.org/10.1117/12.2650773

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