Current research progress on Alzheimer's disease treatment targeting tau protein

Zhimo Jiang

doi:10.1117/12.2668967

24 March 2023 Current research progress on Alzheimer's disease treatment targeting tau protein

Zhimo Jiang

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261148 (2023) https://doi.org/10.1117/12.2668967
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Alzheimer's disease (AD) mostly occurs in the elderly and is characterized by memory impairment and mental decline. It is a disease of the nervous system and is a degenerative change of nerve cells. It is a universal concern for elder populations, however, so far, we have not found a cure for the disease, we only got ways to allocate the progression of the disease. There are two wide-accepted pathological hypotheses for AD: tau tangles, and β-amyloid plaque. While extensive research is done with the β-amyloid pathological mechanism, our knowledge related to tau protein remains relatively less. Evidence suggested that regulating the formation of tau protein-induced NFT, thus restraining the intermediate molecules, potentiates the treatment of AD. Thereby, this review summarizes the pathological mechanism of abnormal tau proteins and recent therapeutic progress in targeting different parts of the tau protein's mechanical pathway.

Citation Download Citation

Zhimo Jiang "Current research progress on Alzheimer's disease treatment targeting tau protein", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261148 (24 March 2023); https://doi.org/10.1117/12.2668967

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