The role of quercetin and curcumin in the treatment of COVID-19 infection: potential for combination of natural compounds

Yueqi Zhang

doi:10.1117/12.2669977

24 March 2023 The role of quercetin and curcumin in the treatment of COVID-19 infection: potential for combination of natural compounds

Yueqi Zhang

Author Affiliations +

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126116C (2023) https://doi.org/10.1117/12.2669977
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

SARS-CoV-2 was originally discovered in China in late 2019 and is a member of the family of enveloped, single-strand RNA viruses known as Betacorona-virus in the Coronaviridae. Since then, it has spread throughout the entire world, generating the COVID-19 epidemic, which has a high infectivity and mortality rate. Nowadays, remdesivir and a few other neutralizing antibodies have been used extensively to treat COVID-19, and other medications are now being found to have anti-coronavirus properties both in vitro and in vivo. Remdesivir's therapeutic outcomes are debatable, though, and the world still needs new antiviral medications imminently. Quercetin and curcumin, both natural compounds derived from plants, may be an option for patients with COVID-19 as a kind of treatment. Molecular docking indicates the great ability of treating COVID-19, and the combination in use may be allowed based on similar mechanisms for treating SARS-CoV-2. This review aims to summarize the role of quercetin and curcumin acting as anti-coronavirus agents, point out the lack of clinical trials of their combined use, and emphasize the use of natural compounds in treating COVID-19.

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Yueqi Zhang "The role of quercetin and curcumin in the treatment of COVID-19 infection: potential for combination of natural compounds", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126116C (24 March 2023); https://doi.org/10.1117/12.2669977

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KEYWORDS

COVID 19

Proteins

Molecular interactions

Clinical trials

Inflammation

Molecules

Viruses

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