Multi-modal functional sensorless adaptive optics for small animal retinal imaging

Jun Song; Yusi Miao; Joanne A. Matsubara; Marinko V. Sarunic; Myeong Jin Ju

doi:10.1117/12.2670968

11 August 2023 Multi-modal functional sensorless adaptive optics for small animal retinal imaging

Jun Song, Yusi Miao, Joanne A. Matsubara, Marinko V. Sarunic, Myeong Jin Ju

Proceedings Volume 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V; 126320N (2023) https://doi.org/10.1117/12.2670968
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

The proposed preclinical study investigates pathological characteristics of retinal diseases such as Age-related Macular Degeneration (AMD) with transgenic small animal models using a multi-modal functional small animal retinal imaging system. For characterizing the animal models, we visualize the melanin concentration, lipofuscin accumulation, and choriocapillaris using a single imaging system. The system implements Polarization-Sensitive Optical Coherence Tomography (PS-OCT), fluorescence Scanning Laser Ophthalmoscope (fSLO), and Sensorless Adaptive Optics (SAO) for the visualizations of pathological features. As preliminary data, we acquired three different mice models and visualized the outer retinal thickness and melanin concentration. The newly developing system is expected to provide multilateral perspectives for further studies in AMD, enabling vision scientists to investigate the correlations between melanin, lipofuscin, and choriocapillaris for the root cause of AMD.

Citation Download Citation

Jun Song, Yusi Miao, Joanne A. Matsubara, Marinko V. Sarunic, and Myeong Jin Ju "Multi-modal functional sensorless adaptive optics for small animal retinal imaging", Proc. SPIE 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V, 126320N (11 August 2023); https://doi.org/10.1117/12.2670968

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