Infrared (IR) lasers are being tested as an alternative to radiofrequency (RF) and ultrasonic (US) devices for hemostatic sealing of vascular tissues. In recent studies, a side-firing optical fiber was reciprocated, producing a linear laser beam pattern for sealing blood vessels. Challenges include limited field-of-view of vessel position within the device jaws, and matching fiber scan length to vessel size. A transparent jaw may improve visibility and enable custom treatment. Quartz and sapphire square optical chambers (2.7 x 2.7 x 25mm OD) were tested with a 1470nm laser and 550-μm-core fiber. Peak temperatures and cooling times were recorded on chamber surfaces. Angle polished fiber tips delivered 94% of light at a 90° angle. Porcine renal arteries with diameters of 3.4±0.7mm (n=13) for quartz and 3.2±0.7mm (n=14) for sapphire (P>0.05), were sealed using 30W for 5s. Reflection losses were 3.3% and 7.4% for quartz and sapphire. Peak temperatures on external chamber surface averaged 74±8 °C and 73±10 °C (P>0.05). Times to cool down to 37 °C measured 13±4s and 27±7s (P<0.05). Vessel burst pressures (BP) averaged 883±393mmHg and 412±330mmHg (P<0.05). For quartz, 13/13 (100%) vessels were sealed (BP>360mmHg), versus 9/14 (64%) for sapphire. Quartz provided more consistent seals and shorter cooling times than sapphire.
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