Whole-eye OCT imaging of refractive errors in genetically modified zebrafish

Shiva Sabour; Cherie A. Brown-Panton; Anna Kotova; Georg S. O. Zoidl; Christiane Zoidl; Georg R. Zoidl; Nima Tabatabaei

doi:10.1117/12.3001760

12 March 2024 Whole-eye OCT imaging of refractive errors in genetically modified zebrafish

Shiva Sabour, Cherie A. Brown-Panton, Anna Kotova, Georg S. O. Zoidl, Christiane Zoidl, Georg R. Zoidl, Nima Tabatabaei

Proceedings Volume 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; 128300D (2024) https://doi.org/10.1117/12.3001760
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Refractive errors, such as myopia and hyperopia, are a major cause of visual impairment worldwide. The genetic basis of refractive errors is becoming increasingly understood, and the zebrafish has emerged as a powerful model organism for studying these disorders. In this study, we present evidence that establishes a connection between the mammalian connexin-36 (Cx36) ortholog gjd2b/Cx35.1, a key component of electrical synapses in zebrafish, as well as connexin-27(Cx27.5), and the occurrence of refractive errors. We investigated the morphological and behavioral changes in adult zebrafish. To assess these changes, we utilized a custom-developed 1310nm optical coherence tomography system for analysis of the entire eye. This analysis revealed development of hyperopic shifts in Cx35.1 knockouts, primarily due to a reduction in eye axial length, while no refractive anomalies were observed in Cx27.5 knockouts.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Shiva Sabour, Cherie A. Brown-Panton, Anna Kotova, Georg S. O. Zoidl, Christiane Zoidl, Georg R. Zoidl, and Nima Tabatabaei "Whole-eye OCT imaging of refractive errors in genetically modified zebrafish", Proc. SPIE 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, 128300D (12 March 2024); https://doi.org/10.1117/12.3001760

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KEYWORDS

Optical coherence tomography

Eye

Error analysis

Imaging systems

Genetics

Visualization

Control systems

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